QQ客服 官方微博 反馈留言

	Exploring phenotype-associated modules in an oral cavity tumor using an integrated framework
	Sun, Zhirong ; Luo, Jie ; Zhou, Yun ; Luo, Junjie ; Liu, Ke ; Li, Wenting
	2010-10-12 ; 2010-10-12
关键词	GENE-EXPRESSION DATA PROTEIN-INTERACTION FUNCTIONAL MODULES BIOLOGICAL NETWORKS CANCER METASTASIS INTERACTOME DATABASE UPDATE Biochemical Research Methods Biotechnology & Applied Microbiology Computer Science, Interdisciplinary Applications Mathematical & Computational Biology Statistics & Probability
中文摘要	Motivation: Like most human diseases, tumors are complex traits, the genesis and development of which recruit a number of genes and several important biological processes. As proteins involved in common processes tend to be centralized in the same local area of protein-protein interaction networks, here a novel framework has been developed to identify which areas of the networks are most relevant to a phenotype. Results: These areas termed 'coherent modules' can be regarded as gene sets dynamically defined in the networks. Compared with previous analogous approaches, one critical feature of our method is the optimization of coherent modules for two distinct aspects balanced by tuning a parameter in the framework. First, we seek the low coupling between coherent modules and then maximize the intrinsic similarity within a module. The framework has good expansibility, with classical expression data analysis methods generalized as particular cases. This coherent module approach was applied to an oral cavity tumor dataset with 18 significant coherent modules identified, which could indicate the presence of lymph node metastasis. Further examination shows that most of the modules are responsible for comparatively independent biological processes. Our framework is helpful for the prognosis of tumors and offers a new perspective for tumor research.
语种	英语 ; 英语
出版者	OXFORD UNIV PRESS ; OXFORD ; GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/81851]
专题	清华大学
推荐引用方式 GB/T 7714	Sun, Zhirong,Luo, Jie,Zhou, Yun,et al. Exploring phenotype-associated modules in an oral cavity tumor using an integrated framework[J],2010, 2010.
APA	Sun, Zhirong,Luo, Jie,Zhou, Yun,Luo, Junjie,Liu, Ke,&Li, Wenting.(2010).Exploring phenotype-associated modules in an oral cavity tumor using an integrated framework..
MLA	Sun, Zhirong,et al."Exploring phenotype-associated modules in an oral cavity tumor using an integrated framework".(2010).

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。