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	Controlling the Degradation of Covalently Cross-linked Carboxymethyl Chitosan Utilizing Bimodal Molecular Weight Distribution
	Lu Guangyuan ; Sheng Baiyang ; Wang Gan ; Wei Yujun ; Gong Yandao ; Zhang Xiufang
	2010-10-12 ; 2010-10-12
关键词	tissue engineering EDC cross-linking biocompatibility bimodal MWD IN-VITRO NERVE REGENERATION HYDROGEL CHITIN Engineering, Biomedical Materials Science, Biomaterials
中文摘要	Degradability is often a critical property of materials utilized in tissue engineering. Although chitosan, a naturally derived polysaccharide, is an attractive material due to its biocompatibility and ability to form scaffolds, its slow and uncontrollable rate of degradation can be an undesirable feature. In this study, we characterize chitosan derivatives formed using a combination of carboxymethylation and a bimodal molecular weight distribution. Specifically, chitosan is carboxymethylated to a theoretical extent of similar to 30% as described in our previous work, in which carboxyl groups possessing negative charges are created at a physiological pH. Carboxymethyl chitosan is used to form films and constructs by varying the ratio of high to low molecular weight (MW) while maintaining the mechanical properties of the polymer. The rate of degradation is found to be dependent upon both the carboxymethylation and the ratio of high to low MW polymer, as determined by dry weight loss in lysozyme solution in PBS. Subsequently, biocompatibility is examined to determine the effects of these modifications upon Neuro-2a cells cultured on these films. Neuro-2a cells adher and proliferate on the modified films at a comparable rate to those cultured on unmodified films. This data indicates that these chitosan derivatives exhibit tunable degradation rates and result in a promising material system for neural tissue engineering.
语种	英语 ; 英语
出版者	SAGE PUBLICATIONS LTD ; LONDON ; 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/81833]
专题	清华大学
推荐引用方式 GB/T 7714	Lu Guangyuan,Sheng Baiyang,Wang Gan,et al. Controlling the Degradation of Covalently Cross-linked Carboxymethyl Chitosan Utilizing Bimodal Molecular Weight Distribution[J],2010, 2010.
APA	Lu Guangyuan,Sheng Baiyang,Wang Gan,Wei Yujun,Gong Yandao,&Zhang Xiufang.(2010).Controlling the Degradation of Covalently Cross-linked Carboxymethyl Chitosan Utilizing Bimodal Molecular Weight Distribution..
MLA	Lu Guangyuan,et al."Controlling the Degradation of Covalently Cross-linked Carboxymethyl Chitosan Utilizing Bimodal Molecular Weight Distribution".(2010).

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