Amyloid beta (1-42) Folding Multiplicity and Single-Molecule Binding Behavior Studied with STM | |
Ma, Xiaojing ; Liu, Lei ; Mao, Xiaobo ; Niu, Lin ; Deng, Ke ; Wu, Weihui ; Li, Yanmei ; Yang, Yanlian ; Wang, Chen | |
2010-10-12 ; 2010-10-12 | |
关键词 | A beta(42) assembly structures single-molecule binding behavior STM SCANNING-TUNNELING-MICROSCOPY SOLID-STATE NMR ATOMIC-FORCE MICROSCOPY ALZHEIMERS-DISEASE IMAGE-CONTRAST EXPERIMENTAL CONSTRAINTS SUBSTITUTED ALKANES SOLVENT PROTECTION CHIRAL RECOGNITION SHEET STRUCTURE Biochemistry & Molecular Biology |
中文摘要 | The fine folding and assembling characteristics of amyloid beta (A beta) peptides are important to pharmaceutical studies of drug molecules and to the pathological analysis of neurodegenerative disorders such as Alzheimer's disease at the molecular level. Here we present observations of the multiple folding characteristics of amyloid peptide A beta(42) lamellae using scanning tunneling microscopy. Molecularly resolved core regions of A beta(42) hairpins and unfolded peptide assembly structures are identified. The parallel assembling characteristics of A beta(42) hairpins can be confirmed in the study. In addition, single-molecule binding characteristics of Congo red and thioflavin T have been shown to bind at the groove regions of peptide assemblies. This Study demonstrates a complementary venue for studying molecular heterogeneity of peptide assemblies, as well as the binding characteristics of molecular modulators. (C) 2009 Elsevier Ltd. All rights reserved. |
语种 | 英语 ; 英语 |
出版者 | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD ; LONDON ; 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND |
内容类型 | 期刊论文 |
源URL | [http://hdl.handle.net/123456789/80952] ![]() |
专题 | 清华大学 |
推荐引用方式 GB/T 7714 | Ma, Xiaojing,Liu, Lei,Mao, Xiaobo,et al. Amyloid beta (1-42) Folding Multiplicity and Single-Molecule Binding Behavior Studied with STM[J],2010, 2010. |
APA | Ma, Xiaojing.,Liu, Lei.,Mao, Xiaobo.,Niu, Lin.,Deng, Ke.,...&Wang, Chen.(2010).Amyloid beta (1-42) Folding Multiplicity and Single-Molecule Binding Behavior Studied with STM.. |
MLA | Ma, Xiaojing,et al."Amyloid beta (1-42) Folding Multiplicity and Single-Molecule Binding Behavior Studied with STM".(2010). |
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