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	ESI-MSn study on the fragmentation of protonated cyclic-dipeptides
	Guo, Yan-Chun ; Cao, Shu-Xia ; Zong, Xiang-Kun ; Liao, Xin-Cheng ; Zhao, Yu-Fen
	2010-10-12 ; 2010-10-12
关键词	Cyclic dipeptides electrospray ionization mass spectrometry fragmentation pathway TANDEM MASS-SPECTROMETRY DIKETOPIPERAZINES IDENTIFICATION MS/MS Spectroscopy
中文摘要	Cyclic dipeptides are relatively simple compounds that can exhibit a great variety of important biological activities. The fragmentation pathways of protonated cyclic dipeptides have been studied by electrospray ionization multistage mass spectrometry (ESI-MSn). The mass spectra studies of the cyclic dipeptides showed that the cyclic dipeptides with the similar substituents, the side chains of amino acid residues at the diketopiperazine ring, followed the same fragmentation pathway. In the fragmentation spectra of protonated cyclic dipeptides, some characteristic fragment ions were observed and could be used to distinguish the cyclic dipeptides. The hydrogen/deuterium (H/D) exchange experiment and the high-resolution mass spectrometry (Q-TOF) were used to verify and rationalize the proposed fragmentation pathways. These observations may have some potential applications in the structural elucidation and interpretation of the mass spectra of homologous compounds.
语种	英语 ; 英语
出版者	IOS PRESS ; AMSTERDAM ; NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/80820]
专题	清华大学
推荐引用方式 GB/T 7714	Guo, Yan-Chun,Cao, Shu-Xia,Zong, Xiang-Kun,et al. ESI-MSn study on the fragmentation of protonated cyclic-dipeptides[J],2010, 2010.
APA	Guo, Yan-Chun,Cao, Shu-Xia,Zong, Xiang-Kun,Liao, Xin-Cheng,&Zhao, Yu-Fen.(2010).ESI-MSn study on the fragmentation of protonated cyclic-dipeptides..
MLA	Guo, Yan-Chun,et al."ESI-MSn study on the fragmentation of protonated cyclic-dipeptides".(2010).

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