| 新生儿畸形380例分析 | |
| 郑卫红 ; 鲁桦 ; 陈恩玲 ; 郭立杰 ; 马瑛 ; 夏恩菊 ; ZHENG Wei-Hong ; LU Hua ; CHEN En-ling ; GUO Li-Jie ; MA Ying ; XIA En-ju | |
| 2010-06-09 ; 2010-06-09 | |
| 关键词 | 新生儿疾病和畸形 产前诊断 早期干预措施 Neonatal diseases and abnormalities Prenatal diagnosis Early intervention R722.1 |
| 其他题名 | Analysis for 380 cases with neonatal deformity |
| 中文摘要 | 目的通过分析本院28年来380例新生儿畸形资料,了解畸形儿的发生率和畸形儿与孕妇的孕、产次、孕周、新生儿出生体重之间的关系。方法将清华大学第一附属医院1975年至2002年间出生的380例畸形儿和此后出生的相同性别的对照正常儿380例的资料进行回顾性统计分析。结果本院该时期畸形儿的发生率为9.54‰(380/39833),神经管畸形、消化道畸形与运动系统畸形居前三位。神经管畸形中,母亲为农民者较城市职工多,差异有统计学意义(P<0.01)。畸形儿组与对照组比较早产发生率显著增高(P<0.01),畸形儿组的平均孕产次较对照组高。畸形儿染色体检查率为10.0%,染色体异常检出率为50.0%。1980年后致死性畸形的发生率明显降低,而非致死性畸形发生率无明显减少,差异有统计学意义(P<0.01)。结论畸形的发生与孕妇的职业、孕周、孕产次及染色体异常有关,加强产前监测和产前诊断,积极采取出生缺陷干预措施,可减少致死性畸形的发生。; Objective To study prevalence of neonatal deformity and its relationship to mothers′numbers of gravida and parity, gestational weeks and birth weight of the newborns by analyzing the data of 380 neonates with deformities.Methods The data of 380 deformed newborns born at the First Affiliated Hospital of Qinghua University in Beijing during 1975 to 2002, as well as normal newborns matched on age and gender born in the same years, were analyzed retrospectively.Results Prevalence of neonatal deformity at the hospital was 9.54‰ (380/39 833), with deformations in neural tubes, digestive tract and kinetic system as the top three sites.Prevalence of neural tubes defects was higher in newborns born to mothers of farmer than that in mothers of urban employees, with significant difference (P<0.01). Prevalence of deformations was significantly higher (P<0.01) in newborns of premature births than that in those of term births. The average number of gravid of mothers with deformed newborns was more than that in control mothers. Chromosome examinations were performed for 10% of the deformed newborns, with abnormality in 50% of them. Prevalence of lethal deformities decreased significantly since 1980 (P<0.01), but no decrease was found in prevalence of non-lethal deformities.Conclusions Occurrence of neonatal deformities related to the mothers′ occupation, gestational weeks, numbers of gravida and parity, and abnormal chromosome in babies. It is suggested to strengthen prenatal surveillance and diagnosis and active implementation of intervention for birth defects, in order to reduce prevalence of lethal deformities. |
| 语种 | 中文 ; 中文 |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/59067]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | 郑卫红,鲁桦,陈恩玲,等. 新生儿畸形380例分析[J],2010, 2010. |
| APA | 郑卫红.,鲁桦.,陈恩玲.,郭立杰.,马瑛.,...&XIA En-ju.(2010).新生儿畸形380例分析.. |
| MLA | 郑卫红,et al."新生儿畸形380例分析".(2010). |
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