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	盐酸米多君与左旋卡尼汀联合治疗老年透析性低血压的临床研究
	李文歌 ; 王廉一 ; Li Wenge ; Wang Lianyi
	2010-06-09 ; 2010-06-09
关键词	血液透析性低血压 老年 盐酸米多君 左旋卡尼汀 intradialytic hypotension elderly midodrine hydrochloride L-carnitine R692.5 R544.2
其他题名	Effects of midodrine hydrochloride and L-carnitine on intradialytic hypotension in elderly patients with hemodialysis
中文摘要	目的探讨盐酸米多君与左旋卡尼汀联合治疗对老年(≥60岁)透析性低血压的疗效和机制。方法观察了盐酸米多君(5~7.5mg/每次透析)与左旋卡尼汀(2g/周)联合治疗12周,对17例老年透析性低血压患者血液透析过程中血压下降的防治作用,以及对心脏功能改善和血浆中左旋卡尼汀水平提高的疗效。结果17例老年透析性低血压患者经过盐酸米多君与左旋卡尼汀联合治疗4~12周,血液透析过程中收缩压和舒张压下降幅度有了明显减小,与治疗前比较具有显著统计学意义(P<0.05),患者心脏左室收缩和舒张功能有了明显改善,血浆中左旋卡尼汀水平也有了大幅度提高。结论盐酸米多君与左旋卡尼汀联合治疗,对老年透析性低血压的防治具有较显著疗效,其机制可能与改善患者心脏功能和提高血浆中左旋卡尼汀的水平等有关。; Objective To investigate effects of the combinative therapy of midodrine hydrochloride and L-carnitine on intradialytic hypotension and its mechanism in elderly patients (sixty year old or above) with hemodialysis. Methods Seventeen elderly patients with intradialytic hypotension underwent the study. Declines of blood pressure during hemodialysis, cardiac output, and plasma L-carnitine level were measured before and after the treatment of midodrine hydrochloride (5~7.5mg/when hemodialysis) and L-carnitine (2g/week) for twelve weeks. Results After the combinative therapy of midodrine hydrochloride and L-carnitine for four and twelve weeks, the declines of systolic and diastolic blood pressure during hemodialysis were significantly reduced compared to those before receiving the treatment (P<0.05). Cardiac output and plasma L-carnitine level were also markedly increased after receiving the treatmen. Conclusion The combinative treatment of midodrine hydrochloride and L-carnitine has significantly therapeutic effects on intradialytic hypotensin in elderly patients with hemodialysis, which may be through increasing cardiac output and L-carnitine level.
语种	中文 ; 中文
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/58901]
专题	清华大学
推荐引用方式 GB/T 7714	李文歌,王廉一,Li Wenge,等. 盐酸米多君与左旋卡尼汀联合治疗老年透析性低血压的临床研究[J],2010, 2010.
APA	李文歌,王廉一,Li Wenge,&Wang Lianyi.(2010).盐酸米多君与左旋卡尼汀联合治疗老年透析性低血压的临床研究..
MLA	李文歌,et al."盐酸米多君与左旋卡尼汀联合治疗老年透析性低血压的临床研究".(2010).

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