| 白术抗炎活性成分的研究 | |
| 董海燕 ; 董亚琳 ; 贺浪冲 ; 裴渭静 ; DONG Hai-yan ; DONG Ya-lin ; HE Lang-chong ; PEI Wei-jing | |
| 2010-06-07 ; 2010-06-07 | |
| 关键词 | 白术 化学成分 抗炎活性 Atractylodes macrocephala Koidz. chemical constituents anti-inflammatory activity R284 |
| 其他题名 | Studies on Constituents and Anti-Inflammatory Activity of Rhizoma Atractylodis macrocephalae |
| 中文摘要 | 目的对白术(Atractylodes macrocephala Koidz.)的抗炎活性成分进行研究。方法采用正相、反相硅胶柱色谱对白术中的化合物进行分离,依据理化性质、波谱数据分析进行结构鉴定,采用整体动物试验,对各成分进行初步抗炎作用研究,结果从白术中分离鉴定5个化合物,分别为白术内酯Ⅲ(Ⅰ)、白术内酯Ⅰ(Ⅱ)、12-异戊烯酰-14-乙酰-2E,8E,10E-三烯-4,6-二炔-1-醇(Ⅲ)、12-α-甲基丁酰-14-乙酰-2E,8E,10E-三烯-4,6-二炔-1-醇(Ⅳ-1)、12-β-甲基丁酰-14-乙酰-2E,8E,10E-三烯-4,6-二炔-1-醇(Ⅳ-2)。抗炎结果表明,上述各成分对小白鼠急性炎症模型均有一定的抗炎作用。结论白术中含对小白鼠急性炎症模型有一定作用的抗炎活性成分,其中化合物Ⅲ及化合物Ⅳ-113C-NMR波谱数据为首次报道。化合物Ⅳ-2数据为首次报道。; OBJECTIVE To study the constituents of Atractylodes macrocephala Koidz. and its anti-inflammatory activity.METHODS The chemical components were isolated by silica gel column chromatography. Their structures were identified by spectral analysis. The anti-inflammatory pharmacological experiments of the constituents were carried out in vivo.RESULTS Five compounds were isolated and their structures were established as atractylenolide Ⅲ(Ⅰ), atractylenolideⅠ(Ⅱ), 14-Acetoxy-12-senecioyloxytetradeca-2E,8E,10E-trien-4,6-diyn-1-ol(Ⅲ), 14-Acet- oxy-12-α-methylbutyl-2E,8E,10E- trien-4,6- diyn-1-ol (Ⅳ-1) and 14-Acet- oxy-12-β-methylbutyl-2E,8E,10E-trien-4,6-diyn-1-ol(Ⅳ-2). CONCLUSION There are anti-inflammatory constituents in Atractylodes macrocephalae. The 13C-NMR data of compound Ⅲ and Ⅳ-1 are reported for the first time.The data of Ⅳ-2 is reported for the first time. |
| 语种 | 中文 ; 中文 |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/45206]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | 董海燕,董亚琳,贺浪冲,等. 白术抗炎活性成分的研究[J],2010, 2010. |
| APA | 董海燕.,董亚琳.,贺浪冲.,裴渭静.,DONG Hai-yan.,...&PEI Wei-jing.(2010).白术抗炎活性成分的研究.. |
| MLA | 董海燕,et al."白术抗炎活性成分的研究".(2010). |
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