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	The significance of proline-rich tyrosine kinase2 (Pyk2) on hepatocellular carcinoma progression and recurrence
	Sun, C. K. ; Ng, K. T. ; Sun, B. S. ; Ho, J. W. Y. ; Lee, T. K. ; Ng, I. ; Poon, R. T. P. ; Lo, C. M. ; Liu, C. L. ; Man, K. ; Fan, S. T.
	2010-05-11 ; 2010-05-11
关键词	hepatocellular carcinoma recurrence invasiveness proline rich tyrosine kinase2 (Pyk2) disease-free survival FOCAL-ADHESION KINASE LIVER-TRANSPLANTATION INTEGRIN SIGNALS CELL-ADHESION GRAFT SIZE EXPRESSION METASTASIS CANCER EZRIN ACTIVATION Oncology
中文摘要	Understanding the precise molecular mechanisms that trigger liver cancer cell migration and invasion could develop novel therapeutic strategies targeting cancer cell invasion to increase the sensitivity to current treatment modalities. In the current study, 49 patients with hepatocellular carcinoma (HCC) were included prospectively. Liver tumour and adjacent non-tumour tissues were detected for the expression of Proline-rich tyrosine kinase 2 (Pyk2), focal adhesion kinase (FAK), ezrin and fibronectin at protein and/or gene levels. Correlation between the expressions of Pyk2/FAK with the clinical pathological data was analysed. Protein expression of Pyk2 was also examined in a nude mice orthotopic liver tumour model with higher metastatic potential. There were 59% (29 out of 49) and 57% (28 out of 49) of HCC patients with higher levels of Pyk2 and FAK protein/gene expression, respectively. We observed a positive correlation between the protein and gene expression levels of Pyk2 and FAK (P = 0.000, r = 0.875). Overexpression of Pyk2 and FAK was significantly correlated with shorter disease-free survival. Patients with higher levels of Pyk2/FAK had larger tumour size and advanced Edmonson grading. In the animal studies, Pyk2 overexpression was found in infiltrative tumour cells and lung metastatic nodules. In conclusion, overexpression of Pyk2 and FAK was found in nearly 60% of HCC patients and was significantly correlated with poor prognosis. The significance of Pyk2 in HCC invasiveness was confirmed by animal studies.
语种	英语 ; 英语
出版者	NATURE PUBLISHING GROUP ; LONDON ; MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/27768]
专题	清华大学
推荐引用方式 GB/T 7714	Sun, C. K.,Ng, K. T.,Sun, B. S.,et al. The significance of proline-rich tyrosine kinase2 (Pyk2) on hepatocellular carcinoma progression and recurrence[J],2010, 2010.
APA	Sun, C. K..,Ng, K. T..,Sun, B. S..,Ho, J. W. Y..,Lee, T. K..,...&Fan, S. T..(2010).The significance of proline-rich tyrosine kinase2 (Pyk2) on hepatocellular carcinoma progression and recurrence..
MLA	Sun, C. K.,et al."The significance of proline-rich tyrosine kinase2 (Pyk2) on hepatocellular carcinoma progression and recurrence".(2010).

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