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	The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development
	Kazanskaya, Olga ; Ohkawara, Bisei ; Heroult, Melanie ; Wu, Wei ; Maltry, Nicole ; Augustin, Hellmut G. ; Niehrs, Christof
	2010-05-11 ; 2010-05-11
关键词	R-spondin VEGF Placenta Vasculogenesis Wnt Xenopus Mouse ENDOTHELIAL GROWTH-FACTOR HEMATOPOIETIC STEM-CELLS HEAD INDUCTION MOUSE EMBRYO YOLK-SAC DEFINITIVE HEMATOPOIESIS ZEBRAFISH EMBRYOS COMMON PRECURSOR XENOPUS EMBRYOS BLOOD FORMATION Developmental Biology
中文摘要	The vertebrate embryonic vasculature develops from angioblasts, which are specified from mesodermal precursors and develop in close association with blood cells. The signals that regulate embryonic vasculogenesis and angiogenesis are incompletely understood. Here, we show that R-spondin 3 (Rspo3), a member of a novel family of secreted proteins in vertebrates that activate Wnt/beta-catenin signaling, plays a key role in these processes. In Xenopus embryos, morpholino antisense knockdown of Rspo3 induces vascular defects because Rspo3 is essential for regulating the balance between angioblast and blood cell specification. In mice, targeted disruption of Rspo3 leads to embryonic lethality caused by vascular defects. Specifically in the placenta, remodeling of the vascular plexus is impaired. In human endothelial cells, R-spondin signaling promotes proliferation and sprouting angiogenesis in vitro, indicating that Rspo3 can regulate endothelial cells directly. We show that vascular endothelial growth factor is an immediate early response gene and a mediator of R-spondin signaling. The results identify Rspo3 as a novel, evolutionarily conserved angiogenic factor in embryogenesis.
语种	英语 ; 英语
出版者	COMPANY OF BIOLOGISTS LTD ; CAMBRIDGE ; BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL, CAMBS, ENGLAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/27020]
专题	清华大学
推荐引用方式 GB/T 7714	Kazanskaya, Olga,Ohkawara, Bisei,Heroult, Melanie,et al. The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development[J],2010, 2010.
APA	Kazanskaya, Olga.,Ohkawara, Bisei.,Heroult, Melanie.,Wu, Wei.,Maltry, Nicole.,...&Niehrs, Christof.(2010).The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development..
MLA	Kazanskaya, Olga,et al."The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development".(2010).

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