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	Fibrillogenesis of apomyoglobin facilitated by aggregation sequence of yeast Sup35 in various regions
	He, YB ; Tang, HD ; Yi, ZW ; Zhou, H ; Luo, YZ
	2010-05-11 ; 2010-05-11
关键词	apomyoglobin Sup35 aggregation sequence stability fibril formation AMYLOID FIBRILS STRUCTURAL-CHARACTERIZATION NEURODEGENERATIVE DISEASES SACCHAROMYCES-CEREVISIAE PROTEIN PRION CHAIN DETERMINANT MYOGLOBIN REVEALS Biochemistry & Molecular Biology Biophysics Cell Biology
中文摘要	To examine the effect of aggregation sequence QGGYQQQYNP from yeast Sup35 on fibril formation of sperm whale apomyoglobin (apoMb), we constructed several mutants via substitution. Urea-induced unfolding of apoMb confirms that the substitution of the aggregation sequence does not significantly affect the stability of the mutants compared to wild type (WT) at pH 4.2. Under this condition, however, despite the difference in rate most apoMb mutants form fibrils more readily than WT with distinct morphology. These results suggest that the aggregation sequence facilitates fibril assembly of apoMb at acidic pH in vitro and this facilitation depends on the regions replaced. (C) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
语种	英语 ; 英语
出版者	ELSEVIER SCIENCE BV ; AMSTERDAM ; PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/26963]
专题	清华大学
推荐引用方式 GB/T 7714	He, YB,Tang, HD,Yi, ZW,et al. Fibrillogenesis of apomyoglobin facilitated by aggregation sequence of yeast Sup35 in various regions[J],2010, 2010.
APA	He, YB,Tang, HD,Yi, ZW,Zhou, H,&Luo, YZ.(2010).Fibrillogenesis of apomyoglobin facilitated by aggregation sequence of yeast Sup35 in various regions..
MLA	He, YB,et al."Fibrillogenesis of apomyoglobin facilitated by aggregation sequence of yeast Sup35 in various regions".(2010).

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