| Generation of mutants with developmental defects in zebrafish by ENU mutagenesis | |
| Jin, P ; Tian, T ; Sun, ZH ; Meng, AM | |
| 2010-05-11 ; 2010-05-11 ; OCT | |
| 关键词 | zebrafish ENU mutagenesis mutant screening MIDBLASTULA TRANSITION MESODERM INDUCTION MATERNAL CONTROL VERTEBRATE GENES Multidisciplinary Sciences |
| 中文摘要 | As a good model for studying early development of vertebrates, zebrafish (Danio rerio) is attracting more and more attention. Following ENU mutagenesis, 320 F2 families were established. Mutants, which showed defects in epiboly, axis, somite, head, and cardiac and blood systems, were identified by observing morphological changes in F3 embryos. So far, 35 mutant lines have been established, the majority of which showed anomalies in axis and somite formation. These mutant lines provide useful genetic resources for cloning of the mutant genes and for studying mechanisms of early development of vertebrate embryos. |
| 语种 | 英语 ; 英语 |
| 出版者 | SCIENCE CHINA PRESS ; BEIJING ; 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/26932]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | Jin, P,Tian, T,Sun, ZH,et al. Generation of mutants with developmental defects in zebrafish by ENU mutagenesis[J],2010, 2010, OCT. |
| APA | Jin, P,Tian, T,Sun, ZH,&Meng, AM.(2010).Generation of mutants with developmental defects in zebrafish by ENU mutagenesis.. |
| MLA | Jin, P,et al."Generation of mutants with developmental defects in zebrafish by ENU mutagenesis".(2010). |
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