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	Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-like protein 2
	Wang, P ; Yang, G ; Mosier, DR ; Chang, P ; Zaidi, T ; Gong, YD ; Zhao, NM ; Dominguez, B ; Lee, KF ; Gan, WB ; Zheng, H
	2010-05-11 ; 2010-05-11
关键词	Alzheimer's disease amyloid precursor protein neuromuscular junction synaptic vesicles synaptic transmission knock-out mice AXONAL-TRANSPORT CHOLINE-ACETYLTRANSFERASE ALZHEIMERS-DISEASE NERVOUS-SYSTEM DEFICIENT MICE CELL-SURFACE GENE JUNCTION HOMOLOG NEUROTRANSMITTER Neurosciences
中文摘要	Biochemical and genetic studies place the amyloid precursor protein (APP) at the center stage of Alzheimer's disease ( AD) pathogenesis. Although mutations in the APP gene lead to dominant inheritance of familial AD, the normal function of APP remains elusive. Here, we report that the APP family of proteins plays an essential role in the development of neuromuscular synapses. Mice deficient in APP and its homolog APP-like protein 2 (APLP2) exhibit aberrant apposition of presynaptic marker proteins with postsynaptic acetylcholine receptors and excessive nerve terminal sprouting. The number of synaptic vesicles at presynaptic terminals is dramatically reduced. These structural abnormalities are accompanied by defective neurotransmitter release and a high incidence of synaptic failure. Our results identify APP/APLP2 as key regulators of structure and function of developing neuromuscular synapses.
语种	英语 ; 英语
出版者	SOC NEUROSCIENCE ; WASHINGTON ; 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/26741]
专题	清华大学
推荐引用方式 GB/T 7714	Wang, P,Yang, G,Mosier, DR,et al. Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-like protein 2[J],2010, 2010.
APA	Wang, P.,Yang, G.,Mosier, DR.,Chang, P.,Zaidi, T.,...&Zheng, H.(2010).Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-like protein 2..
MLA	Wang, P,et al."Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-like protein 2".(2010).

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