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	Cyclooxygenase-independent effects of aspirin on HT-29 human colon cancer cells, revealed by oligonucleotide microarrays
	Yin, Hongying ; Xu, Hao ; Zhao, Yongchao ; Yang, Weiping ; Cheng, Jing ; Zhou, Yuxiang
	2010-05-11 ; 2010-05-11
关键词	aspirin apoptosis colon cancer cyclooxygenase-2 (COX-2) DNA microarray COLORECTAL-CANCER ADENOCARCINOMA CELLS RISK APOPTOSIS DEATH ACTIVATION EXPRESSION PREVENTION ROFECOXIB INHIBIT Biotechnology & Applied Microbiology
中文摘要	Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) inhibit proliferation of human colon cancer cells in vitro. Transmission electron microscope detected morphological features of apoptosis in the aspirin-treated (5 mM, 72 h) HT-29 cells in which cyclooxygenoase-2 is catalytically inactive. We investigated aspirin-induced genome-wide expression changes in HT-29 cells and further studied the time- and concentration-dependent expression changes in 374 apoptosis-related genes, which is the first to show stimulation of genome-wide expression of HT-29 cells by aspirin. The most marked effects of aspirin are on ribosome assembly and rRNA metabolism, which could explain why the quasi-apoptotic morphological changes are not accompanied by a classical DNA ladder. These findings demonstrate that aspirin induces apoptosis in HT-29 cells, bolstering the hypothesis that apoptosis may be a mechanism by which NSAIDs inhibit colon carcinogenesis.
语种	英语 ; 英语
出版者	SPRINGER ; DORDRECHT ; VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/26728]
专题	清华大学
推荐引用方式 GB/T 7714	Yin, Hongying,Xu, Hao,Zhao, Yongchao,et al. Cyclooxygenase-independent effects of aspirin on HT-29 human colon cancer cells, revealed by oligonucleotide microarrays[J],2010, 2010.
APA	Yin, Hongying,Xu, Hao,Zhao, Yongchao,Yang, Weiping,Cheng, Jing,&Zhou, Yuxiang.(2010).Cyclooxygenase-independent effects of aspirin on HT-29 human colon cancer cells, revealed by oligonucleotide microarrays..
MLA	Yin, Hongying,et al."Cyclooxygenase-independent effects of aspirin on HT-29 human colon cancer cells, revealed by oligonucleotide microarrays".(2010).

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