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	Polycomb group protein RING1B is a direct substrate of Caspases-3 and-9
	Wong, Chung Kai ; Chen, Zhengming ; So, Ka Lun ; Li, Peng
	2010-05-11 ; 2010-05-11
关键词	Ring1B polycomb group protein Caspase-3 Caspase-9 nuclear localization transcriptional repression H2A UBIQUITINATION X-INACTIVATION HISTONE H2A CELL-DEATH APOPTOSIS ACTIVATION GENE INTERACTS IDENTIFICATION DROSOPHILA Biochemistry & Molecular Biology Cell Biology
中文摘要	Both Caspase-3 and Caspase-9 play critical roles in the execution of mitochondria-mediated apoptosis. Caspase-9 binds to Apaf-1 in the presence of cytochrome c and dATP/ATP, and is activated by self-cleavage. Caspase-3 is activated by cleavage of caspase-8 and caspase-9. Over hundred direct caspase-3 substrates are identified whereas only few direct caspase-9 substrates are known. Here, we demonstrate that Ring1B, a component of polycomb protein complex that plays important roles in modulating chromatin structures, is a direct substrate of active caspase-3 and caspase-9 both in vitro and in vivo. The specific cleavage sites for caspase-3 and caspase-9 were mapped to Asp(175) and ASP(208), respectively. Importantly, cleavage of Ring1B by active caspases-3 and caspase-9 triggers the redistribution of Ring1B, from exclusive nuclear localization to even distribution throughout the entire cell. The transcriptional repression activity of Ring1B was also disrupted by caspase cleavage. Our data suggest that caspases-3 and caspase-9 play novel roles in transcription by regulating polycomb protein function through direct cleaving of Ring1B. (c) 2007 Elsevier B.V. All rights reserved.
语种	英语 ; 英语
出版者	ELSEVIER SCIENCE BV ; AMSTERDAM ; PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/26488]
专题	清华大学
推荐引用方式 GB/T 7714	Wong, Chung Kai,Chen, Zhengming,So, Ka Lun,et al. Polycomb group protein RING1B is a direct substrate of Caspases-3 and-9[J],2010, 2010.
APA	Wong, Chung Kai,Chen, Zhengming,So, Ka Lun,&Li, Peng.(2010).Polycomb group protein RING1B is a direct substrate of Caspases-3 and-9..
MLA	Wong, Chung Kai,et al."Polycomb group protein RING1B is a direct substrate of Caspases-3 and-9".(2010).

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