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	Manufacture of multimicrotubule chitosan nerve conduits with novel molds and characterization in vitro
	Ao, Q ; Wang, AJ ; Cao, WL ; Zhang, L ; Kong, LJ ; He, Q ; Gong, YD ; Zhang, XF
	2010-05-11 ; 2010-05-11
关键词	nerve conduits tissue engineering chitosan phase separation mold CELL AFFINITY REGENERATION SCAFFOLDS FILMS DEGRADATION DELIVERY FIBERS CHITIN VIVO GAP Engineering, Biomedical Materials Science, Biomaterials
中文摘要	Multimicrotubule chitosan conduits (M-conduits) were fabricated using novel molds and a thermal-induced phase-separation technique. Hollow chitosan conduits (H-conduits) with an inner diameter of 1-5 mm and a wall thickness of 0.2-1.0 mm were made, and then a novel mold composed of a styrofoam insulating pedestal with several holes and a stainless steel cover plate was used to make M-conduits. In brief, corresponding H-conduits were inserted upright into the holes of the styrofoam pedestal, and filled with chitosan solution, then rapidly covered with the precooled stainless steel cover plate, and then placed in a freezer. The styrofoam insulating pedestal enclosing the conduits could reduce the heat transfer through the side wall of the conduits. Gradual phase separation then occurred uniaxially in the presence of a unidirectional temperature gradient from the top end to the bottom end of the chitosan conduits. The phase-separated polymer/solvent systems were then dried in a freeze-dryer. The microtubule diameters were controlled by adjusting the polymer concentration and cooling temperature. In vitro characterization demonstrated that the mold-based multimicrotubule chitosan conduits possessed suitable mechanical strength, microtubule\ diameter distribution, porosity, swelling, biodegradability, and nerve cell affinity, and so they showed potential for application as nerve tissue engineering scaffolds. (c) 2005 Wiley Periodicals, Inc.
语种	英语 ; 英语
出版者	WILEY-LISS ; HOBOKEN ; DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/26475]
专题	清华大学
推荐引用方式 GB/T 7714	Ao, Q,Wang, AJ,Cao, WL,et al. Manufacture of multimicrotubule chitosan nerve conduits with novel molds and characterization in vitro[J],2010, 2010.
APA	Ao, Q.,Wang, AJ.,Cao, WL.,Zhang, L.,Kong, LJ.,...&Zhang, XF.(2010).Manufacture of multimicrotubule chitosan nerve conduits with novel molds and characterization in vitro..
MLA	Ao, Q,et al."Manufacture of multimicrotubule chitosan nerve conduits with novel molds and characterization in vitro".(2010).

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