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	Collagen-based implants reinforced by chitin fibres in a goat shank bone defect model
	Li, XM ; Feng, QL ; Liu, XH ; Dong, W ; Cui, FH
	2010-05-10 ; 2010-05-10
关键词	bone defect chitin fibres reinforce histology radiography ACID) FOAM SCAFFOLDS IN-VITRO COMPOSITE DEGRADATION FIBROBLASTS OSTEOBLASTS BIOREACTOR CARTILAGE CULTURE INVITRO Engineering, Biomedical Materials Science, Biomaterials
中文摘要	Tissue engineering is an increasingly popular method for repairing bone defects. However, repair of bone defects over 30 turn using tissue-engineering methods is a difficult clinical problem. In this study, we used a goat shank model to evaluate the bone-regenerating efficacy of a novel nano-hydroxyapatite/collagen/PLLA (nHACP) composite reinforced by chitin fibres. Forty adult male goats with 40 mm defects in shank at the same anatomic site were divided into four groups. The first group was the control, where nothing was implanted in the defect (defect group). The other three groups were implanted with porous pure PLLA, nHACP and nHACP reinforced by chitin fibres, respectively. Bone growth in each group was evaluated by radiography, histology, bone mineral density and mechanical strength, once every 5 weeks for 15 weeks. The results indicated that nHACP implants, both with and without chitin fibres, are better for repairing the defects than pure PLLA. However, only the reinforced implants showed nearly perfect recovery in 15 weeks after operation. So, the reinforced scaffold might be a candidate for bone tissue repair. (C) 2005 Elsevier Ltd. All rights reserved.
语种	英语 ; 英语
出版者	ELSEVIER SCI LTD ; OXFORD ; THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/21912]
专题	清华大学
推荐引用方式 GB/T 7714	Li, XM,Feng, QL,Liu, XH,et al. Collagen-based implants reinforced by chitin fibres in a goat shank bone defect model[J],2010, 2010.
APA	Li, XM,Feng, QL,Liu, XH,Dong, W,&Cui, FH.(2010).Collagen-based implants reinforced by chitin fibres in a goat shank bone defect model..
MLA	Li, XM,et al."Collagen-based implants reinforced by chitin fibres in a goat shank bone defect model".(2010).

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