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	Chemical characteristics and cytocompatibility of collagen-based scaffold reinforced by chitin fibers for bone tissue engineering
	Li, XM ; Feng, QL ; Wang, WJ ; Cui, FZ
	2010-05-10 ; 2010-05-10
关键词	cell culture bone scaffolds reinforce chitin fibers MESENCHYMAL STEM-CELLS COLORIMETRIC ASSAY IN-VITRO INVITRO PROLIFERATION COMPOSITE POLYMERS CYTOTOXICITY FIBROBLASTS DEGRADATION Engineering, Biomedical Materials Science, Biomaterials
中文摘要	Chitin is a kind of seemly material to match PLLA for a scaffold, which may create an appropriate environment for the regeneration of tissues. In this study, we prepared and evaluated a new nano-hydroxyapatite/coliagen/PLLA (nHACP) scaffold reinforced by chitin fibers for bone-tissue engineering. The chitin fibers were crosslinked with PLLA by dicyclohexylcarbodimide (DCC). The chemical characteristics were evaluated by Fourier transformed infrared (FTIR) spectroscopy and X-ray photoelectron spectroscopy (XPS). The mechanical strength was measured by compressive tests. The fibers, crosslinked with PLLA, could enhance the compressive strength of the scaffold about four times. Human marrow mesenchymal stem cells (MSCs) culture showed that the reinforced nHACP scaffolds were more cytocompatible than that without reinforcement. The crosslinks hardly affected the cytocompatibillity of the reinforced scaffolds. The results suggested that the reinforced scaffolds (DCC crosslinked) might be a promising candidate for bone-tissue engineering. (c) 2005 Wiley Periodicals, Inc.
语种	英语 ; 英语
出版者	WILEY-LISS ; HOBOKEN ; DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/21007]
专题	清华大学
推荐引用方式 GB/T 7714	Li, XM,Feng, QL,Wang, WJ,et al. Chemical characteristics and cytocompatibility of collagen-based scaffold reinforced by chitin fibers for bone tissue engineering[J],2010, 2010.
APA	Li, XM,Feng, QL,Wang, WJ,&Cui, FZ.(2010).Chemical characteristics and cytocompatibility of collagen-based scaffold reinforced by chitin fibers for bone tissue engineering..
MLA	Li, XM,et al."Chemical characteristics and cytocompatibility of collagen-based scaffold reinforced by chitin fibers for bone tissue engineering".(2010).

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