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	Adenine detection by photonic crystal fiber based surface enhanced Raman scattering probe
	Mingshan Li ; Changxi Yang ; He Yan ; Guofan Jin ; Lantian Hou ; Guiyao Zhou
	2010-05-10 ; 2010-05-10
会议名称	Proceedings of the SPIE - The International Society for Optical Engineering ; Optoelectronic Devices and Integration II ; Beijing, China ; INSPEC
关键词	Practical Experimental/ biochemistry biosensors fibre optic sensors gold holey fibres molecular biophysics nanoparticles photonic crystals probes surface enhanced Raman scattering/ adenine detection photonic crystal fiber surface enhanced Raman scattering probe biological samples detection SERS probe biomolecule detection near infrared excitation label-free detection gold nanoparticles PCF air holes/ A8760F Optical and laser radiation (medical uses) A8715D Physical chemistry of biomolecular solutions condensed states A4270Q Photonic bandgap materials A4281P Fibre optic sensors fibre gyros A8780B Biosensors B7510J Optical and laser radiation (biomedical imaging/measurement) B4110 Optical materials B7230J Biosensors B7230E Fibre optic sensors
中文摘要	Detection of biological samples in low concentration is of great significance to the basic research in science, the development of medical technology and many other fields related to our lives. Surface-enhanced Raman scattering (SERS), well-known as a powerful analytical tool with high sensitivity, is especially suitable for biomolecule detection as it enables near infrared (NIR) excitation and label-free detection. SERS probe made of conventional optical fiber provides better flexibility in detection; however, it requires a complicated fabrication process and doesn't serve as a well-set detecting platform. In this talk we propose and demonstrate a photonic crystal fiber (PCF) based SERS probe, which has the new advantages of simplicity in fabrication, better light confinement and increased light-analyte interaction volume. The PCF-based SERS probes are prepared in three different ways: mixed solution of sample and gold nanoparticles filled in air holes of PCF, sample solution dried in gold coated air holes and sample solution filled in gold coated air holes, respectively. Sample solution of adenine is in concentration of about 10/sup -6/ M. Almost every characteristic peak of adenine can be observed in the spectra detected by each of the three probes.
会议录出版者	SPIE - The International Society for Optical Engineering ; USA
语种	英语 ; 英语
内容类型	会议论文
源URL	[http://hdl.handle.net/123456789/19285]
专题	清华大学
推荐引用方式 GB/T 7714	Mingshan Li,Changxi Yang,He Yan,et al. Adenine detection by photonic crystal fiber based surface enhanced Raman scattering probe[C]. 见:Proceedings of the SPIE - The International Society for Optical Engineering, Optoelectronic Devices and Integration II, Beijing, China, INSPEC.

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