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	Preparation and characterization of PLA/fibroin composite and culture of HepG2 (human hepatocellular liver carcinoma cell line) cells
	Lv, Qiang ; Hu, Kun ; Feng, Qingling ; Cui, Fuzhai ; Cao, Chuanbao
	2010-05-10 ; 2010-05-10
会议名称	COMPOSITES SCIENCE AND TECHNOLOGY ; International Symposium on Nanomechanics and Nanocomposites ; Beijing, PEOPLES R CHINA ; Web of Science
关键词	PLA fibroin hepatic tissue engineering biocompatible SILK FIBROIN BIODEGRADABLE POLYMERS HYBRID SPONGE COLLAGEN SCAFFOLD MATRICES GROWTH BIOMATERIALS CULTIVATION ATTACHMENT Materials Science, Composites
中文摘要	Through adding insoluble fibroin microparticles into polylactic acid (PLA) solution, stirring intensively and then freeze-drying the blend, we prepared a composite scaffold composed of polylactic acid (PLA) and fibroin. Observation of the PLA/fibroin composite scaffold by scanning electron microscopy (SEM) showed that fibroin microparticles uniformly distributed in PLA matrix and interconnected pore structures were formed in the scaffolds. The in vitro cell culture result showed that the HepG2 (human hepatocellular liver carcinoma cell line) cells attached and spread well on the surfaces of the composite scaffold. Compared with that on PLA scaffolds, the attachment and growth of HepG2 on the composite scaffold were greatly improved. HepG2 cells attached on the hybrid sponges and established cell-cell contacts to form aggregates with a size up to 100 mu m. Considering that the PLA skeleton facilitated the desired shape formation, and fibroin microparticles improved the cell growth, the PLA/fibroin composite scaffold is a promising matrix for hepatic tissue engineering. (C) 2007 Elsevier Ltd. All rights reserved.; Chinese Acad Sci, Tech Inst Phys & Chem
会议录出版者	ELSEVIER SCI LTD ; OXFORD ; THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
语种	英语 ; 英语
内容类型	会议论文
源URL	[http://hdl.handle.net/123456789/18446]
专题	清华大学
推荐引用方式 GB/T 7714	Lv, Qiang,Hu, Kun,Feng, Qingling,et al. Preparation and characterization of PLA/fibroin composite and culture of HepG2 (human hepatocellular liver carcinoma cell line) cells[C]. 见:COMPOSITES SCIENCE AND TECHNOLOGY, International Symposium on Nanomechanics and Nanocomposites, Beijing, PEOPLES R CHINA, Web of Science.

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