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	Hyaluronic acid hydrogels with IKVAV peptides for tissue repair and axonal regeneration in an injured rat brain
	Wei, Y. T. ; Tian, W. M. ; Yu, X. ; Cui, F. Z. ; Hou, S. P. ; Xu, Q. Y. ; Lee, In-Seop
	2010-05-10 ; 2010-05-10 ; OCT 19-24, 2006
会议名称	BIOMEDICAL MATERIALS ; 4th Korea-China Symposium on Biomaterials and Nano-Biotechnology ; Jeju Do, SOUTH KOREA ; Web of Science
关键词	SPINAL-CORD-INJURY PHPMA HYDROGEL COLLAGEN GROWTH REGROWTH RECOVERY CHANNELS GUIDANCE LESION Materials Science, Biomaterials
中文摘要	A biocompatible hydrogel of hyaluronic acid with the neurite-promoting peptide sequence of IKVAV was synthesized. The characterization of the hydrogel shows an open porous structure and a large surface area available for cell interaction. Its ability to promote tissue repair and axonal regeneration in the lesioned rat cerebrum is also evaluated. After implantation, the polymer hydrogel repaired the tissue defect and formed a permissive interface with the host tissue. Axonal growth occurred within the microstructure of the network. Within 6 weeks the polymer implant was invaded by host-derived tissue, glial cells, blood vessels and axons. Such a hydrogel matrix showed the properties of neuron conduction. It has the potential to repair tissue defects in the central nervous system by promoting the formation of a tissue matrix and axonal growth by replacing the lost tissue.
会议录出版者	IOP PUBLISHING LTD ; BRISTOL ; DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND
语种	英语 ; 英语
内容类型	会议论文
源URL	[http://hdl.handle.net/123456789/18400]
专题	清华大学
推荐引用方式 GB/T 7714	Wei, Y. T.,Tian, W. M.,Yu, X.,et al. Hyaluronic acid hydrogels with IKVAV peptides for tissue repair and axonal regeneration in an injured rat brain[C]. 见:BIOMEDICAL MATERIALS, 4th Korea-China Symposium on Biomaterials and Nano-Biotechnology, Jeju Do, SOUTH KOREA, Web of Science.

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