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	A molecular-thermodynamic model for the interactions between globular proteins in aqueous solutions: Applications to bovine serum albumin (BSA), lysozyme, alpha-chymotrypsin, and immuno-gamma-globulins (IgG) solutions
	Jin, Lin ; Yu, Yang-Xin ; Gao, Guang-Hua
	2010-05-07 ; 2010-05-07
关键词	osmotic pressure globular proteins Yukawa potential bovine serum albumin lysozyme alpha-chymotrypsin IgG equation of state MEAN SPHERICAL APPROXIMATION 2 YUKAWA POTENTIALS FREE-SOLVENT MODEL OSMOTIC-PRESSURES ELECTROLYTE-SOLUTIONS SALINE SOLUTIONS PREDICTION FLUIDS STATE PH Chemistry, Physical
中文摘要	To investigate globular protein-protein and protein-salt interactions in electrolyte solutions, a potential of mean force including hard-core repulsion, van der Waals attraction and electric double layer repulsion is proposed in this work. Both van der Waals attraction and double-layer repulsion are represented using hard spheres with two-Yukawa tails. The explicit analytical solution of osmotic pressure is derived from the first-order mean spherical approximation. From the comparison between the calculated and experimental values of osmotic pressures for aqueous bovine serum albumin (BSA), lysozyme, alpha-chymotrypsin, and immuno-gamma-globulins (IgG) solutions, we found that the proposed model is adequate for the description of the interactions between proteins at low ionic strength and small self-association of protein molecules. At high ionic strength, the charge inversions of protein molecules should be taken into account. (c) 2006 Elsevier Inc. All rights reserved.
语种	英语 ; 英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE ; SAN DIEGO ; 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/17741]
专题	清华大学
推荐引用方式 GB/T 7714	Jin, Lin,Yu, Yang-Xin,Gao, Guang-Hua. A molecular-thermodynamic model for the interactions between globular proteins in aqueous solutions: Applications to bovine serum albumin (BSA), lysozyme, alpha-chymotrypsin, and immuno-gamma-globulins (IgG) solutions[J],2010, 2010.
APA	Jin, Lin,Yu, Yang-Xin,&Gao, Guang-Hua.(2010).A molecular-thermodynamic model for the interactions between globular proteins in aqueous solutions: Applications to bovine serum albumin (BSA), lysozyme, alpha-chymotrypsin, and immuno-gamma-globulins (IgG) solutions..
MLA	Jin, Lin,et al."A molecular-thermodynamic model for the interactions between globular proteins in aqueous solutions: Applications to bovine serum albumin (BSA), lysozyme, alpha-chymotrypsin, and immuno-gamma-globulins (IgG) solutions".(2010).

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