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	Studies on adsorption properties of chemically modified chitosan resins to diuretics
	Chen, F ; Luo, GS ; Wang, YJ
	2010-05-07 ; 2010-05-07
关键词	chemical modified chitosan diuretics adsorption CHROMATOGRAPHY DERIVATIVES BEADS GEL Polymer Science
中文摘要	Four types of chitosan beads, carboxylic chitosan ( SUC-CS), benzoyl chitosan ( BEN-CS), polyethyleneiminated chitosan (PEI-CS) and quaternaminated chitosan (QA-CS) were prepared using the wet phase-inversion method and chemical modification with the chemicals of succinic anhydride, benzoic anhydride, polyethyleneimine and 3-chloro-2-hydroxypropyltrimethyl ammonium chloride. Carboxyl, aromatic acyl, polyethyleneimine and quaternary ammonium groups were induced to chitosan chains, and their structure was characterized by FTIR spectra. The adsorption ability of the chemically modified chitosan resins to nine kinds of diuretics was investigated. The results show that, compared to the unmodified chitosan, the benzoyl chitosan has higher affinity and capacity to almost all the diuretics due to the hydrophobic interaction between chitosan and drug molecule, while the carboxyl chitosan has higher binding affinity only to the basic diuretics. The polyethyleneiminated chitosan has 48% similar to 209% higher capacity to the acidic diuretics due to the increased concentration of amino groups on its chain. The adsorption ability of quaternaminated chitosan for the diuretics with carboxyl group is greatly improved, especially for the bumetanide, which is above 2 times higher than the unmodified one because of the strong interaction of ion exchange.
语种	中文 ; 中文
出版者	SCIENCE CHINA PRESS ; BEIJING ; 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/17176]
专题	清华大学
推荐引用方式 GB/T 7714	Chen, F,Luo, GS,Wang, YJ. Studies on adsorption properties of chemically modified chitosan resins to diuretics[J],2010, 2010.
APA	Chen, F,Luo, GS,&Wang, YJ.(2010).Studies on adsorption properties of chemically modified chitosan resins to diuretics..
MLA	Chen, F,et al."Studies on adsorption properties of chemically modified chitosan resins to diuretics".(2010).

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