| A novel polyamide/Ser-His conjugate with DNA-cleaving function | |
| Niu Ming-Yu ; Ye Yong ; Liu Wei ; Zhang Zhen ; Zhao Yu-Fen | |
| 2010-05-06 ; 2010-05-06 | |
| 关键词 | polyamide/Ser-His conjugate DNA cleavage agent PYRROLE-IMIDAZOLE POLYAMIDES DIPEPTIDE SERYL-HISTIDINE MINOR-GROOVE RECOGNITION LIGANDS DESIGN Chemistry, Multidisciplinary |
| 中文摘要 | Recently, polyamides containing N-methylpyrrole have attracted considerable attention from synthetic and biological chemists. Based on Dervan's theory, the polyamide/Ser-His conjugate which is a synthetic analogue of natural products for DNA affinity was synthesized through the dicyclohexylcarbodiimide/1-hydroxy-benzotriazole(DCC/HOBt) coupling reaction, and its cleavage activity for DNA was also studied. In BR buffer(pH = 6.0), pBR322 DNA can be cleavaged by the title compound at 37 degrees C. After 6 h, pBR 322 DNA was transferred from form I to form II, after 36 h, pBR 322 DNA was cleavaged totally. |
| 语种 | 中文 ; 中文 |
| 出版者 | HIGHER EDUCATION PRESS ; BEIJING ; SHATANHOU ST 55, BEIJING 100009, PEOPLES R CHINA |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/13049]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | Niu Ming-Yu,Ye Yong,Liu Wei,et al. A novel polyamide/Ser-His conjugate with DNA-cleaving function[J],2010, 2010. |
| APA | Niu Ming-Yu,Ye Yong,Liu Wei,Zhang Zhen,&Zhao Yu-Fen.(2010).A novel polyamide/Ser-His conjugate with DNA-cleaving function.. |
| MLA | Niu Ming-Yu,et al."A novel polyamide/Ser-His conjugate with DNA-cleaving function".(2010). |
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