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	Study of photoimmunoconjugates
	Huang Lei ; Zhao Fuqun ; Huang Xin ; Zhang Fushi
	2010-05-06 ; 2010-05-06
关键词	photoimmunoconjugates photoimmunotherapy photosensitizers monoclonal antibodies ANTIBODY-TARGETED PHOTOLYSIS INTERNALIZING MONOCLONAL-ANTIBODIES SQUAMOUS-CELL CARCINOMA HUMAN BLADDER-CARCINOMA OVARIAN-CANCER MODEL PHOTODYNAMIC THERAPY IN-VITRO PHTHALOCYANINE TETRASULFONATE COLORECTAL-CANCER LEUKEMIA-CELLS Chemistry, Multidisciplinary
中文摘要	A photosensitizer coupled to the monoclonal antibody ( MAb) can form photoimmunoconjugate, which has the capability of recognizing tumors. This method overcomes the limitation of low selectivity in the traditional photodynamic therapy of cancers. The development of photoimmunotherapy is reviewed in this paper. For photoimmunotherapy to be successful, sufficient amounts of sensitizer should be coupled to the MAb without altering its biological properties. Recent progress in the synthetic methods and the applications of photoimmunoconjugates are summarized briefly. Based on the applications in the photoimmunotherapy of photoimmunoconjugates, the trends of further development are described including approaches and methods of increasing the photosensitizing capability of photosensitizers and improving the ability of photoimmunoconjugates directly targeting tumors.
语种	中文 ; 中文
出版者	CHINESE ACAD SCIENCES ; BEIJING ; NO. 33 BEISIHUANXILU, ZHONGGUANCUN, BEIJING 100080, PEOPLES R CHINA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/12734]
专题	清华大学
推荐引用方式 GB/T 7714	Huang Lei,Zhao Fuqun,Huang Xin,et al. Study of photoimmunoconjugates[J],2010, 2010.
APA	Huang Lei,Zhao Fuqun,Huang Xin,&Zhang Fushi.(2010).Study of photoimmunoconjugates..
MLA	Huang Lei,et al."Study of photoimmunoconjugates".(2010).

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