| Penta-coordinated phosphorus structure analysis on kinases | |
| Li, W ; Ma, Y ; Zhao, YF | |
| 2010-05-06 ; 2010-05-06 ; OCT | |
| 关键词 | penta-coordinated phosphorus structures kinases DNA-REPLICATION CRYSTAL-STRUCTURE PHOSPHORYLATION CHECKPOINT YEAST Chemistry, Multidisciplinary |
| 中文摘要 | In this paper, based on the known crystal structures of Square Pyramid (SP) and Trigonal Bipyramid (TBP) penta-coordinated phosphorus compounds containing amino acid side chains, such as amino, carboxyl, hydroxyl or thiol, a software designed to survey the P(5)-Structure of phosphorylated proteins. By this software, it was found that 382 of 398 phosphorus-related kinases (96%) from current PDB could go through the penta-coordinated phosphorus transition state or intermediate. For example, in protein 1HE8, amino group in Lysine16 was within 3.58 Angstrom from the phosphorus atom, and a potential TBP structure consisting GNP2 and N-Z could be overlapped with an authentic TBP with an RMSD value of 0.71 Angstrom. |
| 语种 | 英语 ; 英语 |
| 出版者 | SCIENCE CHINA PRESS ; BEIJING ; 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/12384]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | Li, W,Ma, Y,Zhao, YF. Penta-coordinated phosphorus structure analysis on kinases[J],2010, 2010, OCT. |
| APA | Li, W,Ma, Y,&Zhao, YF.(2010).Penta-coordinated phosphorus structure analysis on kinases.. |
| MLA | Li, W,et al."Penta-coordinated phosphorus structure analysis on kinases".(2010). |
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