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	PromoterExplorer: an effective promoter identification method based on the AdaBoost algorithm
	Xie, Xudong ; Wu, Shuanhu ; Lam, Kin-Man ; Yan, Hong
	2010-05-06 ; 2010-05-06
关键词	HUMAN GENOME CPG ISLANDS SEQUENCES PREDICTION RECOGNITION SYSTEM GENES START Biochemical Research Methods Biotechnology & Applied Microbiology Computer Science, Interdisciplinary Applications Mathematical & Computational Biology Statistics & Probability
中文摘要	Motivation: Promoter prediction is important for the analysis of gene regulations. Although a number of promoter prediction algorithms have been reported in literature, significant improvement in prediction accuracy remains a challenge. In this paper, an effective promoter identification algorithm, which is called PromoterExplorer, is proposed. In our approach, we analyze the different roles of various features, that is, local distribution of pentamers, positional CpG island features and digitized DNA sequence, and then combine them to build a high-dimensional input vector. A cascade AdaBoost- based learning procedure is adopted to select the most 'informative' or 'discriminating' features to build a sequence of weak classifiers, which are combined to form a strong classifier so as to achieve a better performance. The cascade structure used for identification can also reduce the false positive. Results: PromoterExplorer is tested based on large- scale DNA sequences from different databases, including the EPD, DBTSS, GenBank and human chromosome 22. Experimental results show that consistent and promising performance can be achieved. Contact: h.yan@cityu.edu.hk.
语种	英语 ; 英语
出版者	OXFORD UNIV PRESS ; OXFORD ; GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/11590]
专题	清华大学
推荐引用方式 GB/T 7714	Xie, Xudong,Wu, Shuanhu,Lam, Kin-Man,et al. PromoterExplorer: an effective promoter identification method based on the AdaBoost algorithm[J],2010, 2010.
APA	Xie, Xudong,Wu, Shuanhu,Lam, Kin-Man,&Yan, Hong.(2010).PromoterExplorer: an effective promoter identification method based on the AdaBoost algorithm..
MLA	Xie, Xudong,et al."PromoterExplorer: an effective promoter identification method based on the AdaBoost algorithm".(2010).

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