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	HtSNPer1.0: software for haplotype block partition and htSNPs selection
	Ding, KY ; Zhang, J ; Zhou, KX ; Shen, Y ; Zhang, XG
	2010-05-06 ; 2010-05-06
关键词	LINKAGE-DISEQUILIBRIUM HUMAN GENOME RECOMBINATION INFERENCE ALGORITHM HISTORY Biochemical Research Methods Biotechnology & Applied Microbiology Mathematical & Computational Biology
中文摘要	Background: There is recently great interest in haplotype block structure and haplotype tagging SNPs (htSNPs) in the human genome for its implication on htSNPs-based association mapping strategy for complex disease. Different definitions have been used to characterize the haplotype block structure in the human genome, and several different performance criteria and algorithms have been suggested on htSNPs selection. Results: A heuristic algorithm, generalized branch-and-bound algorithm, is applied to the searching of minimal set of haplotype tagging SNPs ( htSNPs) according to different htSNPs performance criteria. We develop a software htSNPer1.0 to implement the algorithm, and integrate three htSNPs performance criteria and four haplotype block definitions for haplotype block partitioning. It is a software with powerful Graphical User Interface (GUI), which can be used to characterize the haplotype block structure and select htSNPs in the candidate gene or interested genomic regions. It can find the global optimization with only a fraction of the computing time consumed by exhaustive searching algorithm. Conclusion: htSNPer1.0 allows molecular geneticists to perform haplotype block analysis and htSNPs selection using different definitions and performance criteria. The software is a powerful tool for those focusing on association mapping based on strategy of haplotype block and htSNPs.
语种	英语 ; 英语
出版者	BIOMED CENTRAL LTD ; LONDON ; MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/9682]
专题	清华大学
推荐引用方式 GB/T 7714	Ding, KY,Zhang, J,Zhou, KX,et al. HtSNPer1.0: software for haplotype block partition and htSNPs selection[J],2010, 2010.
APA	Ding, KY,Zhang, J,Zhou, KX,Shen, Y,&Zhang, XG.(2010).HtSNPer1.0: software for haplotype block partition and htSNPs selection..
MLA	Ding, KY,et al."HtSNPer1.0: software for haplotype block partition and htSNPs selection".(2010).

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