Comparative study of porous hydroxyapatite/chitosan and whitlockite/chitosan scaffolds for bone regeneration in calvarial defects

CORC > 上海硅酸盐研究所 > 中国科学院上海硅酸盐研究所 > 生物材料与组织工程研究中心 > 期刊论文

	Comparative study of porous hydroxyapatite/chitosan and whitlockite/chitosan scaffolds for bone regeneration in calvarial defects
	Zhou, Ding 1; Qi, Chao 2; Chen, Yi-Xuan 1; Zhu, Ying-Jie 2; Sun, Tuan-Wei 2; Chen, Feng 2; Zhang, Chang-Qing 1
刊名	INTERNATIONAL JOURNAL OF NANOMEDICINE
	2017
卷号	12 页码:2673-2687
关键词	hydroxyapatite whitlockite chitosan osteogenic differentiation rat critical calvarial defect tissue engineering
英文摘要	Hydroxyapatite (HAP; Ca-10(PO4)(6)(OH)(2)) and whitlockite (WH; Ca18Mg2(HPO4)(2)(PO4)(12)) are widely utilized in bone repair because they are the main components of hard tissues such as bones and teeth. In this paper, we synthesized HAP and WH hollow microspheres by using creatine phosphate disodium salt as an organic phosphorus source in aqueous solution through microwave-assisted hydrothermal method. Then, we prepared HAP/chitosan and WH/chitosan composite membranes to evaluate their biocompatibility in vitro and prepared porous HAP/chitosan and WH/chitosan scaffolds by freeze drying to compare their effects on bone regeneration in calvarial defects in a rat model. The experimental results indicated that the WH/chitosan composite membrane had a better biocompatibility, enhancing proliferation and osteogenic differentiation ability of human mesenchymal stem cells than HAP/chitosan. Moreover, the porous WH/chitosan scaffold can significantly promote bone regeneration in calvarial defects, and thus it is more promising for applications in tissue engineering such as calvarial repair compared to porous HAP/chitosan scaffold.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Nanoscience & Nanotechnology ; Pharmacology & Pharmacy
研究领域[WOS]	Science & Technology - Other Topics ; Pharmacology & Pharmacy
关键词[WOS]	BIOACTIVE GLASS SCAFFOLDS ; IN-VIVO EVALUATION ; CALCIUM-PHOSPHATE ; MAGNESIUM WHITLOCKITE ; TRICALCIUM PHOSPHATE ; HOLLOW MICROSPHERES ; CREATINE-PHOSPHATE ; PROTEIN ADSORPTION ; DRUG-DELIVERY ; OSTEOGENESIS
收录类别	SCI
语种	英语
WOS记录号	WOS:000398661900005
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/23772]
专题	上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文
作者单位	1.Shanghai Jiao Tong Univ, Dept Orthoped Surg, Affiliated Peoples Hosp 6, 600 Yishan Rd, Shanghai 200233, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Dingxi Rd, Shanghai 200050, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Ding,Qi, Chao,Chen, Yi-Xuan,et al. Comparative study of porous hydroxyapatite/chitosan and whitlockite/chitosan scaffolds for bone regeneration in calvarial defects[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2017,12:2673-2687.
APA	Zhou, Ding.,Qi, Chao.,Chen, Yi-Xuan.,Zhu, Ying-Jie.,Sun, Tuan-Wei.,...&Zhang, Chang-Qing.(2017).Comparative study of porous hydroxyapatite/chitosan and whitlockite/chitosan scaffolds for bone regeneration in calvarial defects.INTERNATIONAL JOURNAL OF NANOMEDICINE,12,2673-2687.
MLA	Zhou, Ding,et al."Comparative study of porous hydroxyapatite/chitosan and whitlockite/chitosan scaffolds for bone regeneration in calvarial defects".INTERNATIONAL JOURNAL OF NANOMEDICINE 12(2017):2673-2687.