Modeling and analysis of mechanical properties of single cells

CORC > 沈阳自动化研究所 > 中国科学院沈阳自动化研究所 > 机器人学研究室

	Modeling and analysis of mechanical properties of single cells
	Wang B(王博); Wang WX(王文学); Wang YC(王越超); Liu LQ(刘连庆)
	2016
会议名称	10th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2016
会议日期	October 30 - November 2, 2016
会议地点	Macau, China
关键词	single cell dynamic model mechanical properties principal component analysis atomic force microscopy viscoelasticity
页码	51-54
通讯作者	王文学 ; 刘连庆
中文摘要	Cells can be regarded as a complex network, which contains thousands of criss-cross signal pathways. The mechanical properties of a cell reflect the structure and composition of its cytoskeleton and are closely related to the cellular biological functions and physiological activities. In this study, we develop a dynamical model with cellular viscoelasticity properties as the system parameters to describe the stress-relaxation phenomenon of a single cell under the indentation of atomic force microscope (AFM). The system order and parameters were identified and analyzed. The parameters identified with this model represent the cellular mechanical elasticity and viscosity respectively and can be used to classify cell types and discriminate cellular state.
收录类别	EI
产权排序	1
会议录	2016 IEEE 10th International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2016
会议录出版者	IEEE Computer Society
会议录出版地	Piscataway, NJ, USA
语种	英语
ISSN号	2159-6964
ISBN号	978-1-5090-4675-1
内容类型	会议论文
源URL	[http://ir.sia.cn/handle/173321/20428]
专题	沈阳自动化研究所_机器人学研究室
推荐引用方式 GB/T 7714	Wang B,Wang WX,Wang YC,et al. Modeling and analysis of mechanical properties of single cells[C]. 见:10th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2016. Macau, China. October 30 - November 2, 2016.