Further evidence for the association between LRP8 and schizophrenia

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	Further evidence for the association between LRP8 and schizophrenia
	Xiao X 1; Yu H 2,3,4,5; Chang H 1; Zhang D 2,3; Yue WH[]2,3; Li M[]1; Li J 2,3; Wang L 1; Li LY 1
刊名	Schizophrenia Research
	2017
卷号	期号:页码:In press
关键词	LRP8 rs5177 Schizophrenia mRNA
通讯作者	dryue@bjmu.edu.cn ; limingkiz@mail.kiz.ac.cn
合作状况	其它
英文摘要	Previous studies (including genome-wide association study (GWAS) and candidate gene studies) have revealed the important roles of genetic risk factors in schizophrenia, and RELN has been identified as a risk gene for this illness. We recently found that the low-density lipoprotein receptor-related protein 8 (LRP8), a receptor of Reelin (the protein encoded by RELN), was significantly associated with schizophrenia and bipolar disorder in European populations. To further enhance our understanding of its role in the risk of psychiatric illnesses, we conducted meta-analyses of a higher density of single nucleotide polymorphisms (SNPs, N=173) in LRP8 to understand their associations with schizophrenia in much larger samples (39,400 cases and 50,357 controls) from populations of European, Chinese and African American ancestries. The significant risk SNPs then underwent further analyses to understand their correlations with bipolar disorder and anxiety disorders, as well as LRP8 expression. We observed that rs5177 in the 3' untranslated region (3'UTR) of LRP8 was associated with schizophrenia and other psychiatric disorders, and rs5177 was also associated with LRP8 mRNA expression. These data further support LRP8 as a schizophrenia susceptibility gene, and suggest that this variant is likely a risk locus in general populations
资助信息	This work was supported by CAS Pioneer Hundred Talents Program (to M.L.); the Na- tional Key Research and Development Program (2016YFC1307000) (to W.H.Y.) and the NationalKeyTechnologyR&DProgramofChina(2015BAI13B01)(toD.Z.).Wearegrateful to all the voluntary donors of DNA samples in this study.
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/11484]
专题	昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_转化基因组
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, Chin 2.Peking University Sixth Hospital & Institute of Mental Health, Beijing, China 3.National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China 4.Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, Chin 5.Department of Psychiatry, Jining Medical University, Jining, Shandong, China
推荐引用方式 GB/T 7714	Xiao X,Yu H,Chang H,et al. Further evidence for the association between LRP8 and schizophrenia[J]. Schizophrenia Research,2017,():In press.
APA	Xiao X.,Yu H.,Chang H.,Zhang D.,Yue WH[].,...&Li LY.(2017).Further evidence for the association between LRP8 and schizophrenia.Schizophrenia Research,(*),In press.
MLA	Xiao X,et al."Further evidence for the association between LRP8 and schizophrenia".Schizophrenia Research .(2017):In press.