PolyQ 2.0: an improved version of PolyQ, a database of human polyglutamine proteins

CORC > 天津工业生物技术研究所 > 结构生物信息学和整合系统生物学实验室宋江宁 > 期刊论文

	PolyQ 2.0: an improved version of PolyQ, a database of human polyglutamine proteins
	Li, Chen 1,2; Nagel, Jeremy 1,2; Androulakis, Steve 3; Song, Jiangning 1,2,4,5; Buckle, Ashley M.1,2
刊名	DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
	2016-03-15
英文摘要	Proteins with expanded polyglutamine (polyQ) repeats are involved in human neurodegenerative diseases, via a gain-of-function mechanism of neuronal toxicity involving protein conformational changes that result in the formation and deposition of beta-sheet-rich aggregates. Aggregation is dependent on the context and properties of the host protein, such as domain context and location of the repeat tract. In order to explore this relationship in greater detail, here we describe PolyQ 2.0, an updated database that provides a comprehensive knowledgebase for human polyQ proteins. Compared with the previous PolyQ database, our new database provides a variety of substantial updates including detailed biological annotations and search options. Biological annotations in terms of domain context information, protein structural and functional annotation, single point mutations, predicted disordered regions, protein-protein interaction partners, metabolic/signaling pathways, post-translational modification sites and evolutionary information are made available. Several new database functionalities have also been provided, including search using multiple/combinatory keywords, and submission of new data entries. Also, several third-party plug-ins are employed to enhance data visualization in PolyQ 2.0. In PolyQ 2.0 the proteins are reclassified into 3 new categories and contain 9 reviewed disease-associated polyQ proteins, 105 reviewed non-disease polyQ proteins and 146 un-reviewed polyQ proteins (reviewed by UniProt curators). We envisage that this updated database will be a useful resource for functional and structural investigation of human polyQ proteins.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Mathematical & Computational Biology
研究领域[WOS]	Mathematical & Computational Biology
关键词[WOS]	UBIQUITIN-PROTEASOME SYSTEM ; MACHADO-JOSEPH-DISEASE ; TATA-BINDING PROTEIN ; NEURODEGENERATIVE DISEASES ; SPINOCEREBELLAR ATAXIA ; GENE ; AGGREGATION ; SEQUENCE ; IDENTIFICATION ; VISUALIZATION
收录类别	SCI
语种	英语
WOS记录号	WOS:000374090500001
内容类型	期刊论文
源URL	[http://124.16.173.210/handle/834782/2253]
专题	天津工业生物技术研究所_结构生物信息学和整合系统生物学实验室宋江宁_期刊论文
作者单位	1.Monash Univ, Biomed Discovery Inst, Melbourne, Vic 3800, Australia 2.Monash Univ, Dept Biochem & Mol Biol, Melbourne, Vic 3800, Australia 3.Monash Univ, Monash Bioinformat Platform, Melbourne, Vic 3800, Australia 4.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Natl Engn Lab Ind Enzymes, Tianjin 300308, Peoples R China 5.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Key Lab Syst Microbial Biotechnol, Tianjin 300308, Peoples R China
推荐引用方式 GB/T 7714	Li, Chen,Nagel, Jeremy,Androulakis, Steve,et al. PolyQ 2.0: an improved version of PolyQ, a database of human polyglutamine proteins[J]. DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION,2016.
APA	Li, Chen,Nagel, Jeremy,Androulakis, Steve,Song, Jiangning,&Buckle, Ashley M..(2016).PolyQ 2.0: an improved version of PolyQ, a database of human polyglutamine proteins.DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION.
MLA	Li, Chen,et al."PolyQ 2.0: an improved version of PolyQ, a database of human polyglutamine proteins".DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2016).