The study of the relation of DNA repair pathway genes SNPs and the sensitivity to radiotherapy and chemotherapy of NSCLC

	The study of the relation of DNA repair pathway genes SNPs and the sensitivity to radiotherapy and chemotherapy of NSCLC
	Wang, Chunbo 1,2; Nie, Huan 1; Li, Yiqun 1; Liu, Guiyou 1,3; Wang, Xu 4; Xing, Shijie 1; Zhang, Liping 2; Chen, Xin 2; Chen, Yue 1; Li, Yu 1
刊名	SCIENTIFIC REPORTS
	2016-06-01
卷号	6
英文摘要	To analyze the relation between SNPs in DNA repair pathway-related genes and sensitivity of tumor radio-chemotherapy, 26 SNPs in 20 DNA repair genes were genotyped on 176 patients of NSCLC undertaking radio-chemotherapy treatment. In squamous cell carcinoma (SCC), as the rs2228000, rs2228001 (XPC), rs2273953 (TP73), rs2279744 (MDM2), rs2299939 (PTEN) and rs8178085, rs12334811 (DNA-PKcs) affected the sensitivity to chemotherapy, so did the rs8178085, rs12334811 to radiotherapy. Moreover rs344781, rs2273953 and rs12334811 were related with the survival time of SCC. In general, the "good" genotype GG (rs12334811) showed greater efficacy of radio-chemotherapy and MSF (24 months) on SCC. In adenocarcinoma, as the rs2699887 (PIK3), rs12334811 (DNA-PKcs) influenced the sensitivity to chemotherapy, so did the rs2299939, rs2735343 (PTEN) to radiotherapy. And rs402710, rs80270, rs2279744 and rs2909430 impacted the survival time of the adenocarcinoma patients. Both GG (rs2279744) and AG (rs2909430) showed a shorter survival time (MFS = 6). Additionally, some SNPs such as rs2228000, rs2228001 and rs344781 were found to regulate the expression of DNA repair pathway genes through eQTLs dataset analysis. These results indicate that SNPs in DNA repair pathway genes might regulate the expression and affect the DNA damage repair, and thereby impact the efficacy of radio-chemotherapy and the survival time of NSCLC.
WOS标题词	Science & Technology
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	CELL LUNG-CANCER ; GENOME-WIDE ASSOCIATION ; SINGLE-NUCLEOTIDE POLYMORPHISMS ; PLATINUM-BASED CHEMOTHERAPY ; PROGNOSTIC-SIGNIFICANCE ; PROSTATE-CANCER ; DAMAGE REPAIR ; SURVIVAL ; SUSCEPTIBILITY ; EXPRESSION
收录类别	SCI
语种	英语
WOS记录号	WOS:000376861900001
内容类型	期刊论文
源URL	[http://124.16.173.210/handle/834782/2896]
专题	天津工业生物技术研究所_基因组分析实验室陈祖耕_期刊论文
作者单位	1.Harbin Inst Technol, Sch Life Sci & Technol, Heilongjiang, Peoples R China 2.Harbin Med Univ, Affiliated Tumour Hosp, Dept Radiotherapy, Harbin, Peoples R China 3.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Genome Anal Lab, Beijing 100864, Peoples R China 4.Beijing Miyun Cty Hosp, Dept Radiotherapy, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Wang, Chunbo,Nie, Huan,Li, Yiqun,et al. The study of the relation of DNA repair pathway genes SNPs and the sensitivity to radiotherapy and chemotherapy of NSCLC[J]. SCIENTIFIC REPORTS,2016,6.
APA	Wang, Chunbo.,Nie, Huan.,Li, Yiqun.,Liu, Guiyou.,Wang, Xu.,...&Li, Yu.(2016).The study of the relation of DNA repair pathway genes SNPs and the sensitivity to radiotherapy and chemotherapy of NSCLC.SCIENTIFIC REPORTS,6.
MLA	Wang, Chunbo,et al."The study of the relation of DNA repair pathway genes SNPs and the sensitivity to radiotherapy and chemotherapy of NSCLC".SCIENTIFIC REPORTS 6(2016).