Hierarchical macropore/nano surface regulates stem cell fate through a ROCK-related signaling pathway

CORC > 上海硅酸盐研究所 > 中国科学院上海硅酸盐研究所 > 特种无机涂层重点实验室 > 期刊论文

	Hierarchical macropore/nano surface regulates stem cell fate through a ROCK-related signaling pathway
	Pan, Houhua 1,2,3; Xie, Youtao 1; Zhang, Zequan 1; Li, Kai 1; Hu, Dandan 1; Zheng, Xuebin 1; Tang, Tingting 2
刊名	RSC ADVANCES
	2017
卷号	7 期号:14 页码:8521-8532
英文摘要	A hierarchical macropore/nano implant surface has been considered as an effective approach to endow biomaterials with better osteogenic performance and long-term stability. The involvement of rho-associated kinase (ROCK) in hierarchical surface-induced osteogenesis, which might originate from the synergistic effect of macropores and nanostructures on cytoskeleton distribution, has previously been demonstrated. However, the underlying intracellular mechanisms are still largely unknown, and thus, this precludes the precise understanding of its cell surface interaction. In this study, it has been further proved that a ROCK-related signaling pathway might be important in translating the surface cues into BMSC fate. Results showed that different bone marrow stromal cell (BMSC) cytoskeleton distributions and corresponding ROCK activity, consequently exerted distinct effects on the FAK-ERK1/2 signaling pathway, which was finally responsible for the BMSC osteogenic differentiation performance. This study has indicated the probable role of ROCK-regulated cytoskeleton tension and its downstream signaling pathway in mediating the signals from topography cues for desirable osteogenic differentiation and furthermore, a probably distinct mechanotransduction process concerning different scales of topographies has been proposed, which might provide insights for use in advanced biomaterial surface design to attain better osteogenesis.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Multidisciplinary
研究领域[WOS]	Chemistry
关键词[WOS]	FOCAL ADHESION KINASE ; OSTEOGENIC DIFFERENTIATION ; PROTEIN ADSORPTION ; MECHANOTRANSDUCTION ; TOPOGRAPHY ; MICROTOPOGRAPHY ; PHOSPHORYLATION ; CHEMISTRY ; RHOA/ROCK ; SCALE
收录类别	SCI
语种	英语
WOS记录号	WOS:000393758700052
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/23487]
专题	上海硅酸盐研究所_特种无机涂层重点实验室_期刊论文
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, Key Lab Inorgan Coating Mat, 1295 Dingxi Rd, Shanghai 200050, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Shanghai Key Lab Orthopaed Implants,Dept Orthopae, Shanghai 200011, Peoples R China 3.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Pan, Houhua,Xie, Youtao,Zhang, Zequan,et al. Hierarchical macropore/nano surface regulates stem cell fate through a ROCK-related signaling pathway[J]. RSC ADVANCES,2017,7(14):8521-8532.
APA	Pan, Houhua.,Xie, Youtao.,Zhang, Zequan.,Li, Kai.,Hu, Dandan.,...&Tang, Tingting.(2017).Hierarchical macropore/nano surface regulates stem cell fate through a ROCK-related signaling pathway.RSC ADVANCES,7(14),8521-8532.
MLA	Pan, Houhua,et al."Hierarchical macropore/nano surface regulates stem cell fate through a ROCK-related signaling pathway".RSC ADVANCES 7.14(2017):8521-8532.