Evaluation of zinc-doped mesoporous hydroxyapatite microspheres for the construction of a novel biomimetic scaffold optimized for bone augmentation

CORC > 上海硅酸盐研究所 > 中国科学院上海硅酸盐研究所 > 生物材料与组织工程研究中心 > 期刊论文

	Evaluation of zinc-doped mesoporous hydroxyapatite microspheres for the construction of a novel biomimetic scaffold optimized for bone augmentation
	Yu, Weilin 1; Sun, Tuan-Wei 2,3; Qi, Chao 2,3; Ding, Zhenyu 1; Zhao, Huakun 1; Zhao, Shichang 1; Shi, Zhongmin 1; Zhu, Ying-Jie 2,3; Chen, Daoyun 1; He, Yaohua 1,4
刊名	INTERNATIONAL JOURNAL OF NANOMEDICINE
	2017
卷号	12 页码:2293-2306
关键词	drug delivery mesoporous hydroxyapatite microspheres zinc biomimicry scaffold bone regeneration
英文摘要	Biomaterials with high osteogenic activity are desirable for sufficient healing of bone defects resulting from trauma, tumor, infection, and congenital abnormalities. Synthetic materials mimicking the structure and composition of human trabecular bone are of considerable potential in bone augmentation. In the present study, a zinc (Zn)-doped mesoporous hydroxyapatite microspheres (Zn-MHMs)/collagen scaffold (Zn-MHMs/Coll) was developed through a lyophilization fabrication process and designed to mimic the trabecular bone. The Zn-MHMs were synthesized through a microwave-hydrothermal method by using creatine phosphate as an organic phosphorus source. Zn-MHMs that consist of hydroxyapatite nanosheets showed relatively uniform spherical morphology, mesoporous hollow structure, high specific surface area, and homogeneous Zn distribution. They were additionally investigated as a drug nanocarrier, which was efficient in drug delivery and presented a pH-responsive drug release behavior. Furthermore, they were incorporated into the collagen matrix to construct a biomimetic scaffold optimized for bone tissue regeneration. The Zn-MHMs/Coll scaffolds showed an interconnected pore structure in the range of 100-300 mu m and a sustained release of Zn ions. More importantly, the Zn-MHMs/Coll scaffolds could enhance the osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells. Finally, the bone defect repair results of critical-sized femoral condyle defect rat model demonstrated that the Zn-MHMs/Coll scaffolds could enhance bone regeneration compared with the Coll or MHMs/Coll scaffolds. The results suggest that the biomimetic Zn-MHMs/Coll scaffolds may be of enormous potential in bone repair and regeneration.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Nanoscience & Nanotechnology ; Pharmacology & Pharmacy
研究领域[WOS]	Science & Technology - Other Topics ; Pharmacology & Pharmacy
关键词[WOS]	ORGANIC PHOSPHORUS SOURCE ; PROTEIN ADSORPTION ; DRUG-DELIVERY ; IN-VITRO ; OSTEOGENIC DIFFERENTIATION ; SONOCHEMICAL SYNTHESIS ; HOLLOW MICROSPHERES ; CREATINE-PHOSPHATE ; BIOACTIVE GLASS ; DISODIUM SALT
收录类别	SCI
语种	英语
WOS记录号	WOS:000397274500003
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/23575]
专题	上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文
作者单位	1.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Orthoped, 600 Yishan Rd, Shanghai 200233, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Dingxi Rd, Shanghai 200050, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Sch Biomed Engn, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Yu, Weilin,Sun, Tuan-Wei,Qi, Chao,et al. Evaluation of zinc-doped mesoporous hydroxyapatite microspheres for the construction of a novel biomimetic scaffold optimized for bone augmentation[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2017,12:2293-2306.
APA	Yu, Weilin.,Sun, Tuan-Wei.,Qi, Chao.,Ding, Zhenyu.,Zhao, Huakun.,...&He, Yaohua.(2017).Evaluation of zinc-doped mesoporous hydroxyapatite microspheres for the construction of a novel biomimetic scaffold optimized for bone augmentation.INTERNATIONAL JOURNAL OF NANOMEDICINE,12,2293-2306.
MLA	Yu, Weilin,et al."Evaluation of zinc-doped mesoporous hydroxyapatite microspheres for the construction of a novel biomimetic scaffold optimized for bone augmentation".INTERNATIONAL JOURNAL OF NANOMEDICINE 12(2017):2293-2306.