In vitro and in vivo responses of macrophages to magnesium-doped titanium

CORC > 上海硅酸盐研究所 > 中国科学院上海硅酸盐研究所 > 生物材料与组织工程研究中心 > 期刊论文

	In vitro and in vivo responses of macrophages to magnesium-doped titanium
	Li, Bin 1; Cao, Huiliang 2; Zhao, Yaochao 1; Cheng, Mengqi 1; Qin, Hui 1; Cheng, Tao 1; Hu, Yan 1; Zhang, Xianlong 1; Liu, Xuanyong 2
刊名	SCIENTIFIC REPORTS
	2017-02-15
卷号	7
英文摘要	Modulating immune response to biomaterials through changing macrophage polarization has been proven to be a promising strategy to elicit beneficial outcomes in tissue repair. The objective of this study was to evaluate the response of macrophage polarization to titanium doped with magnesium (0.1 similar to 0.35%), which was prepared through the magnesium plasma immersion ion implantation (Mg PIII) technique. The M1/M2 polarization profile of macrophages was investigated using a murine cell line RAW 264.7 in vitro and a murine air pouch model in vivo. Our results demonstrated that the Mg PIII-treated titanium induced a higher percentage of M2 macrophages and higher concentrations of the anti-inflammatory cytokines interleukin (IL)-4 and IL-10. Genes encoding two growth factors, bone morphogenetic protein 2 (BMP2) and vascular endothelial growth factor (VEGF) were up-regulated, thus indicating the ability of the M2 phenotype to promote wound healing. The nuclear factor kappa B (NF-kappa B) signalling pathway was down-regulated. In vivo the Mg PIII-treated titanium elicited a similar effect on macrophage polarization and induced thinner fibrous capsule formation and a decrease in infiltrated cells. These results indicate that Mg PIII treatment has the immunomodulatory potential to elicit the pro-healing M2-polarized macrophage phenotype, thus providing new insight into the development of immunomodulatory biomaterials.
WOS标题词	Science & Technology
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	NF-KAPPA-B ; FOREIGN-BODY REACTION ; INFLAMMATORY RESPONSES ; REGENERATIVE MEDICINE ; AIR POUCH ; POLARIZATION ; SULFATE ; BIOMATERIALS ; PATHWAY ; SURFACE
收录类别	SCI
语种	英语
WOS记录号	WOS:000394127500001
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/23490]
专题	上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文
作者单位	1.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Dept Orthoped, Shanghai 200233, Peoples R China 2.Chinese Acad Sci, State Key Lab High Performance Ceram & Superfine, Shanghai Inst Ceram, Shanghai 200050, Peoples R China
推荐引用方式 GB/T 7714	Li, Bin,Cao, Huiliang,Zhao, Yaochao,et al. In vitro and in vivo responses of macrophages to magnesium-doped titanium[J]. SCIENTIFIC REPORTS,2017,7.
APA	Li, Bin.,Cao, Huiliang.,Zhao, Yaochao.,Cheng, Mengqi.,Qin, Hui.,...&Liu, Xuanyong.(2017).In vitro and in vivo responses of macrophages to magnesium-doped titanium.SCIENTIFIC REPORTS,7.
MLA	Li, Bin,et al."In vitro and in vivo responses of macrophages to magnesium-doped titanium".SCIENTIFIC REPORTS 7(2017).