Targeting Upconversion Nanoprobes for Magnetic Resonance Imaging of Early Colon Cancer

CORC > 上海硅酸盐研究所 > 中国科学院上海硅酸盐研究所 > 高性能陶瓷和超微结构国家重点实验室 > 期刊论文

	Targeting Upconversion Nanoprobes for Magnetic Resonance Imaging of Early Colon Cancer
	Jin, Yingying 1; Ni, Dalong 2; Zhang, Jiawen 1; Han, Fang 1; Wang, Jing 1; Gao, Lu 1; Zhang, Hua 1; Liu, Yanyan 2; Cui, Zhaowen 2; Yao, Zhenwei 1
刊名	PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
	2017-03-01
卷号	34 期号:3
英文摘要	Colon cancer (CC) is one of the most common intestinal malignancies and is difficult to detect in its early stage by magnetic resonance imaging (MRI) with currently used contrast agents (CAs). The development of targeted CAs contributes to the early diagnosis of CC and thereby enables early intervention and timely therapy. Considering the outstanding performance of upconversion nanoprobes (UCNPs) in high-performance MR and fluorescence imaging, a new type of nanoprobes with considerably enhanced imaging performance is developed herein. Carcinoembryonic antigen (CEA) antibody is conjugated onto the surface of UCNPs to achieve the targeted imaging of early CC tumors, which overexpress CEA. Both toxicity tests and histological/hematological examinations demonstrate the excellent biocompatibility of these CC-targeting nanoprobes, which possess great potential for clinical application in the early diagnosis of CC.
WOS标题词	Science & Technology ; Physical Sciences ; Technology
类目[WOS]	Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]	Chemistry ; Science & Technology - Other Topics ; Materials Science
关键词[WOS]	MRI CONTRAST AGENTS ; ADVANCED COLORECTAL-CANCER ; IN-VIVO ; CIRCULATION TIME ; QUANTITATIVE MRI ; STAGE-II ; NANOPARTICLES ; DELIVERY ; ANTIBODY ; TUMOR
收录类别	SCI
语种	英语
WOS记录号	WOS:000398089100003
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/23685]
专题	上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文
作者单位	1.Fudan Univ, Huashan Hosp, Dept Radiol, 12 Middle Urumqi Rd, Shanghai 200040, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Dingxi Rd, Shanghai 200050, Peoples R China 3.East China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Sch Chem & Mol Engn, Shanghai 200062, Peoples R China
推荐引用方式 GB/T 7714	Jin, Yingying,Ni, Dalong,Zhang, Jiawen,et al. Targeting Upconversion Nanoprobes for Magnetic Resonance Imaging of Early Colon Cancer[J]. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,2017,34(3).
APA	Jin, Yingying.,Ni, Dalong.,Zhang, Jiawen.,Han, Fang.,Wang, Jing.,...&Bu, Wenbo.(2017).Targeting Upconversion Nanoprobes for Magnetic Resonance Imaging of Early Colon Cancer.PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,34(3).
MLA	Jin, Yingying,et al."Targeting Upconversion Nanoprobes for Magnetic Resonance Imaging of Early Colon Cancer".PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION 34.3(2017).