Food restriction affects Y-maze spatial recognition memory in developing mice

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	Food restriction affects Y-maze spatial recognition memory in developing mice
	Fu Y[]1; Chen YM 1; Wang JH[]2; Li LE 1; Wang YM 1; Kong XY 1
刊名	International Journal of Developmental Neuroscience
	2017
卷号	60 期号:X 页码:8-15
关键词	Food restriction Developing mice Spatial recognition memory Y-maze Chronic Acute
通讯作者	fuyu@kmust.edu.cn ; wjh16@hotmail.com
英文摘要	The ambiguous effects of food restriction (FR) on cognition in rodents have been mostly explored in the aged brain by a variety of paradigms, in which either rewards or punishments are involved. This study aims to examine the effects of chronic and acute FR with varying intensities on spatial recognition memory in developing mice. We have used a Y-maze task that is based on the innate tendency of rodents to explore novel environments. In chronic FR, mice had 70%-30% chow of control for seven weeks. In acute FR, mice were food restricted for 12-48h before the tests. We found that chronic FR had no effect on the preference of mice for novelty in the Y-maze, but severe FR (50%-30% of control) caused impairment on spatial recognition memory. The impairment significantly correlated with the slow weight growth induced by FR. Acute FR also did not affect the novelty preference of mice, but either improved or impaired the memory retention. These data suggest chronic FR impairs Y-maze spatial recognition memory in developing mice depending on FR intensity and individual tolerability of the FR. Moreover, acute FR exerts diverse effects on the memory, either positive or negative. Our findings have revealed new insights on the effects of FR on spatial recognition memory in developing animals.
资助信息	This work was supported by the National Science Foundation of China (81560221, 81560234, 31571109, 31560317, 61502214, and 81460007), the Research Foundation of Kunming University of Science and Technology (KKZ3201560006), and the Natural Science Foundation of Yunnan Province of China (2016FB107).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/11051]
专题	昆明动物研究所_神经系统编码昆明动物研究所_中国科学院昆明灵长类研究中心
作者单位	1.Medical Faculty, Kunming University of Science &Technology, Kunming, Yunnan 650500, PR China 2.Kunming Primates Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, PR China
推荐引用方式 GB/T 7714	Fu Y[],Chen YM,Wang JH[],et al. Food restriction affects Y-maze spatial recognition memory in developing mice[J]. International Journal of Developmental Neuroscience,2017,60(X):8-15.
APA	Fu Y[],Chen YM,Wang JH[],Li LE,Wang YM,&Kong XY.(2017).Food restriction affects Y-maze spatial recognition memory in developing mice.International Journal of Developmental Neuroscience,60(X),8-15.
MLA	Fu Y[*],et al."Food restriction affects Y-maze spatial recognition memory in developing mice".International Journal of Developmental Neuroscience 60.X(2017):8-15.