A tree shrew glioblastoma model recapitulates features of human glioblastoma

CORC > 昆明动物研究所 > 昆明动物研究所 > 中国科学院昆明灵长类研究中心

	A tree shrew glioblastoma model recapitulates features of human glioblastoma
	Tong YH 1,2; Hao JJ 3; Li Y 2,4,7; Lv LB 6; Wang F 5; Iavarone A 8; Zhao XD[*]2,6; Tu Q 2,4; Yu HL 5; Yan LZ 2,6
刊名	Oncotarget
	2017
卷号	期号:页码:published online
关键词	glioblastoma animal model tree shrew P53
通讯作者	zhaoxudong@mail.kiz.ac.cn
英文摘要	Tupaia belangeri (tree shrew), an animal species whose genome has significantly higher similarity to primates than rodents, has been used in biomedical research. To generate animal models that reproduce the human tumors more faithfully than rodents, we present the first report of a cancer model mimicking human tumor genetics in tree shrew. By engineering a lentiviral system for the transduction of mutant H-Ras and a shRNA against tree shrew p53, we successfully generated malignant glioma in tree shrew. The tree shrew glioma exhibited aggressive behavior and a relatively short latency, and markedly reduced animal survival. Remarkably, the biological features of human high-grade glioma (necrosis, microvascular proliferation, pseudopalisading) were all present in tree shrew glioma. Furthermore, genetic analysis of tree shrew glioma revealed that the tumors were clustered within the mesenchymal subgroup of human glioblastoma multiforme. Compared with the corresponding mouse glioma, tree shrew gliomas were markedly more similar to human glioblastoma at gene expression profile. The tree shrew glioma model provides colleagues working in the field of gliomas and cancer in general with a more accurate animal model.
收录类别	SCI
资助信息	This work was supported in part by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA 01040403), the National Natural Science Foundation of China (NSFC, 81171960), the Top Talents Program of Yunnan Province, China (2012HA014), research program of tree shrew as laboratory animal from CAS (zsys- 02) to XZ and CAS “light of west China” program to YL.
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10867]
专题	昆明动物研究所_中国科学院昆明灵长类研究中心昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_遗传资源与进化国家重点实验室昆明动物研究所_进化与功能基因组学昆明动物研究所_肿瘤干细胞生物学
作者单位	1.School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China 3.State Key Lab of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 4.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China 5.Department of Neurological Surgery, The First Affiliated Hospital, Kunming Medical University, Kunming, Yunnan, 650032, China 6.Kunming Primate Research Center, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 7.Kunming University of science and technology, Kunming, Yunnan, 650500, China 8.Institute for Cancer Genetics, Columbia University, New York, New York 10032, USA
推荐引用方式 GB/T 7714	Tong YH,Hao JJ,Li Y,et al. A tree shrew glioblastoma model recapitulates features of human glioblastoma[J]. Oncotarget,2017,():published online.
APA	Tong YH.,Hao JJ.,Li Y.,Lv LB.,Wang F.,...&Yan LZ.(2017).A tree shrew glioblastoma model recapitulates features of human glioblastoma.Oncotarget,(),published online.
MLA	Tong YH,et al."A tree shrew glioblastoma model recapitulates features of human glioblastoma".Oncotarget .(2017):published online.