Synergistic in vivo photodynamic and photothermal antitumor therapy based on collagen-gold hybrid hydrogels with inclusion of photosensitive drugs

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	Synergistic in vivo photodynamic and photothermal antitumor therapy based on collagen-gold hybrid hydrogels with inclusion of photosensitive drugs
	Sun, Jiajia 1; Guo, Ying 1; Xing, Ruirui 2,3; Jiao, Tifeng 3; Zou, Qianli 2; Yan, Xuehai 2
刊名	COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
	2017-02-05
卷号	514 页码:155-160
关键词	Collagen hydrogel Self-assembly Photodynamic therapy Photothermal therapy Anticancer
ISSN号	0927-7757
英文摘要	Phototherapies, including photodynamic therapy (PDT) and photothermal therapy (PTT), have shown great potential in non-invasive tumor treatments. To achieve targeted and effective antitumor therapy, it is highly desirable to combine the advantages of PDT and PTT in a delivery platform. Herein, we report a strategy to achieve synergistic PDT and PTT based on collagen-gold hybrid hydrogels, in which gold nanoparticles are incorporated as photothermal agents for PTT and photosensitive drugs are entrapped as photodynamic agents for PDT. In vivo antitumor results reveal that synergistic PDT and PTT exhibit the best antitumor effect with a tumor elimination rate up to 80% while PDT and PTT alone show less effective tumor inhibition. This synergistic therapy by the designed hydrogels does not cause body weight loss as compared to the control group without any treatment. Taken together, such a therapeutic strategy based on collagen-gold hybrid hydrogels with inclusion of photosensitive drugs may provide new alternatives for developing a type of delivery nanosystems toward synergistic antitumor therapy. (C) 2016 Published by Elsevier B.V.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Physical
研究领域[WOS]	Chemistry
关键词[WOS]	PROTEIN ; CANCER ; GROWTH ; VITRO
收录类别	SCI
语种	英语
WOS记录号	WOS:000390366400018
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/21860]
专题	过程工程研究所_生化工程国家重点实验室
作者单位	1.Harbin Univ Sci & Technol, Sch Chem & Environm Engn, Harbin 150080, Peoples R China 2.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 3.Yanshan Univ, Sch Environm & Chem Engn, Hebei Key Lab Appl Chem, Qinhuangdao 066004, Peoples R China
推荐引用方式 GB/T 7714	Sun, Jiajia,Guo, Ying,Xing, Ruirui,et al. Synergistic in vivo photodynamic and photothermal antitumor therapy based on collagen-gold hybrid hydrogels with inclusion of photosensitive drugs[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2017,514:155-160.
APA	Sun, Jiajia,Guo, Ying,Xing, Ruirui,Jiao, Tifeng,Zou, Qianli,&Yan, Xuehai.(2017).Synergistic in vivo photodynamic and photothermal antitumor therapy based on collagen-gold hybrid hydrogels with inclusion of photosensitive drugs.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,514,155-160.
MLA	Sun, Jiajia,et al."Synergistic in vivo photodynamic and photothermal antitumor therapy based on collagen-gold hybrid hydrogels with inclusion of photosensitive drugs".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 514(2017):155-160.