Terahertz identification and quantification of neurotransmitter and neurotrophy mixture

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	Terahertz identification and quantification of neurotransmitter and neurotrophy mixture
	Peng, Y; Yuan, XR; Zou, X; Chen, WQ; Huang, H; Zhao, HW; Song, B; Chen, L; Zhu, YM
刊名	BIOMEDICAL OPTICS EXPRESS
	2016
卷号	7 期号:11 页码:4472-4479
ISSN号	2156-7085
通讯作者	Chen, L (reprint author), Fudan Univ, Hua Shan Hosp, Shanghai 200040, Peoples R China.
英文摘要	Terahertz spectroscopy has been widely used for investigating the fingerprint spectrum of different substances. For cancerous tissues, the greatest difficulty is the absorption peaks of various substances contained in tissues overlap with each other, which are hard to identify and quantitative analyze. As a result, it is very hard to measure the presence of cancer cell and then to diagnose accurately. In this paper, we select three typical neurotransmitters (gamma-aminobutyric acid, L-glutamic acid, dopamine hydrochloride) and two typical metabolites (inositol and creatine) in neurons to measure their terahertz spectra with different mixture ratios. By choosing characteristic absorption peaks, removing baseline and using the least square method, we can identify the components and proportions of each mixture, where the goodness of fit to practical situation is up to 94%. These results provide important evidences for identifying nerve substances and obtaining exact quantitative analysis. (C) 2016 Optical Society of America
收录类别	SCI
语种	英语
WOS记录号	WOS:000387557600010
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/26650]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
推荐引用方式 GB/T 7714	Peng, Y,Yuan, XR,Zou, X,et al. Terahertz identification and quantification of neurotransmitter and neurotrophy mixture[J]. BIOMEDICAL OPTICS EXPRESS,2016,7(11):4472-4479.
APA	Peng, Y.,Yuan, XR.,Zou, X.,Chen, WQ.,Huang, H.,...&Zhu, YM.(2016).Terahertz identification and quantification of neurotransmitter and neurotrophy mixture.BIOMEDICAL OPTICS EXPRESS,7(11),4472-4479.
MLA	Peng, Y,et al."Terahertz identification and quantification of neurotransmitter and neurotrophy mixture".BIOMEDICAL OPTICS EXPRESS 7.11(2016):4472-4479.