Quantum dots protect against MPP+-induced neurotoxicity in a cell model of Parkinson's disease through autophagy induction | |
Wang, L; Li, XM; Han, YP; Wang, T; Zhao, Y; Ali, A; El-Sayed, NN; Shi, JY; Wang, WF; Fan, CH | |
刊名 | SCIENCE CHINA-CHEMISTRY |
2016 | |
卷号 | 59期号:11页码:1486-1491 |
关键词 | quantum dots autophagy Parkinson's disease alpha-Synuclein Beclin1 |
ISSN号 | 1674-7291 |
通讯作者 | Chen, N (reprint author), Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, CAS Key Lab Interfacial Phys & Technol, Div Phys Biol,Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China. ; Chen, N (reprint author), Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, CAS Key Lab Interfacial Phys & Technol, Bioimaging Ctr,Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China. ; Zhao, Y (reprint author), Sichuan Univ, Sch Life Sci, Chengdu 610064, Peoples R China. |
英文摘要 | Autophagy is a basic cellular process that decomposes damaged organelles and aberrant proteins. Dysregulation of autophagy is implicated in pathogenesis of neurodegenerative disorders, including Parkinson's disease (PD). Pharmacological compounds that stimulate autophagy can provide neuroprotection in models of PD. Nanoparticles have emerged as regulators of autophagy and have been tested in adjuvant therapy for diseases. In this present study, we explore the effects of quantum dots (QDs) that can induce autophagy in a cellular model of Parkinson's disease. CdTe/CdS/ZnS QDs protect differentiated rat pheochromocytoma PC12 cells from MPP+-induced cell damage, including reduced viability, apoptosis and accumulation of alpha-Synuclein, a characteristic protein of PD. The protective function of QDs is autophagy-dependent. In addition, we investigate the interaction between quantum dots and autophagic pathways and identify beclin1 as an essential factor for QDs-induced autophagy. Our results reveal new promise of QDs in the theranostic of neurodegenerative diseases. |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000387571100016 |
内容类型 | 期刊论文 |
源URL | [http://ir.sinap.ac.cn/handle/331007/26611] |
专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
推荐引用方式 GB/T 7714 | Wang, L,Li, XM,Han, YP,et al. Quantum dots protect against MPP+-induced neurotoxicity in a cell model of Parkinson's disease through autophagy induction[J]. SCIENCE CHINA-CHEMISTRY,2016,59(11):1486-1491. |
APA | Wang, L.,Li, XM.,Han, YP.,Wang, T.,Zhao, Y.,...&Chen, N.(2016).Quantum dots protect against MPP+-induced neurotoxicity in a cell model of Parkinson's disease through autophagy induction.SCIENCE CHINA-CHEMISTRY,59(11),1486-1491. |
MLA | Wang, L,et al."Quantum dots protect against MPP+-induced neurotoxicity in a cell model of Parkinson's disease through autophagy induction".SCIENCE CHINA-CHEMISTRY 59.11(2016):1486-1491. |
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