The effects of plasma electrolytically oxidized NiTi on in vitro endothelialization | |
Huan, Z.1; Yu, H.2; Li, H.2; Ruiter, M. S.3; Chang, J.1,2; Apachitei, I.4; Duszczyk, J.4; de Vries, C. J. M.3; Fratila-Apachitei, L. E.4 | |
刊名 | COLLOIDS AND SURFACES B-BIOINTERFACES |
2016-05-01 | |
卷号 | 141页码:365-373 |
关键词 | Nitinol Plasma electrolytic oxidation Stents Endothelial cells Junction proteins |
英文摘要 | The role of biomaterials surface in controlling the interfacial biological events leading to implant integration is of key importance. In this study, the effects of NiTi surfaces treated by plasma electrolytic oxidation (PEO) on human umbilical vein endothelial cells (HUVECs) have been investigated. The changes in NiTi surface morphology and chemistry were assessed by SEM, XPS and cross-section TEM/EDX analyzes whereas the effects of the resultant surfaces on in vitro endothelialization and cell junction proteins have been evaluated by life/dead staining, SEM, cells counting, qPCR and immunofluorescence. The findings indicated that the PEO-treated NiTi, with a microporous morphology and oxide dominated surface chemistry, supports viability and proliferation of HUVECs. Numerous thin filopodia probing the microporous surface assisted cells attachment. In addition, claudin-5 and occludin have been upregulated and expression of vascular endothelial-cadherin was not suppressed on PEO-treated NiTi relative to the reference electropolished surfaces. The results of this study suggest that novel NiTi surfaces may be developed using the PEO process, which can be of benefit to atherosclerosis treatment. (C) 2016 Elsevier B.V. All rights reserved. |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences ; Technology |
类目[WOS] | Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials |
研究领域[WOS] | Biophysics ; Chemistry ; Materials Science |
关键词[WOS] | DRUG-ELUTING STENTS ; VASCULAR-PERMEABILITY ; BIOMEDICAL APPLICATIONS ; STAINLESS-STEEL ; RESTENOSIS ; THROMBOSIS ; SURFACES ; CELLS ; IMPLANTATION ; DYSFUNCTION |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000374197700042 |
内容类型 | 期刊论文 |
源URL | [http://ir.sic.ac.cn/handle/331005/23054] |
专题 | 上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文 |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, 1295 Dingxi Rd, Shanghai 200050, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Biomed Engn, Med X Res Inst, 1954 Huashan Rd, Shanghai 200030, Peoples R China 3.Univ Amsterdam, Acad Med Ctr, Dept Med Biochem, Meibergdreef 15, NL-1105 AZ Amsterdam, Netherlands 4.Delft Univ Technol, Dept BioMech Engn, NL-2628 CD Delft, Netherlands |
推荐引用方式 GB/T 7714 | Huan, Z.,Yu, H.,Li, H.,et al. The effects of plasma electrolytically oxidized NiTi on in vitro endothelialization[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2016,141:365-373. |
APA | Huan, Z..,Yu, H..,Li, H..,Ruiter, M. S..,Chang, J..,...&Fratila-Apachitei, L. E..(2016).The effects of plasma electrolytically oxidized NiTi on in vitro endothelialization.COLLOIDS AND SURFACES B-BIOINTERFACES,141,365-373. |
MLA | Huan, Z.,et al."The effects of plasma electrolytically oxidized NiTi on in vitro endothelialization".COLLOIDS AND SURFACES B-BIOINTERFACES 141(2016):365-373. |
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