Silicon-Doped Titanium Dioxide Nanotubes Promoted Bone Formation on Titanium Implants | |
Zhao, Xijiang1,2; Wang, Tao1; Qian, Shi3; Liu, Xuanyong3; Sun, Junying1; Li, Bin1 | |
刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |
2016-03-01 | |
卷号 | 17期号:3 |
关键词 | MC3T3-E1 cells silicon doping titanium dioxide nanotubes osteogenic differentiation osseointegration titanium |
英文摘要 | While titanium (Ti) implants have been extensively used in orthopaedic and dental applications, the intrinsic bioinertness of untreated Ti surface usually results in insufficient osseointegration irrespective of the excellent biocompatibility and mechanical properties of it. In this study, we prepared surface modified Ti substrates in which silicon (Si) was doped into the titanium dioxide (TiO2) nanotubes on Ti surface using plasma immersion ion implantation (PIII) technology. Compared to TiO2 nanotubes and Ti alone, Si-doped TiO2 nanotubes significantly enhanced the expression of genes related to osteogenic differentiation, including Col-I, ALP, Runx2, OCN, and OPN, in mouse pre-osteoblastic MC3T3-E1 cells and deposition of mineral matrix. In vivo, the pull-out mechanical tests after two weeks of implantation in rat femur showed that Si-doped TiO2 nanotubes improved implant fixation strength by 18% and 54% compared to TiO2-NT and Ti implants, respectively. Together, findings from this study indicate that Si-doped TiO2 nanotubes promoted the osteogenic differentiation of osteoblastic cells and improved bone-Ti integration. Therefore, they may have considerable potential for the bioactive surface modification of Ti implants. |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
类目[WOS] | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry |
关键词[WOS] | OSTEOBLAST-LIKE CELL ; SUBSTITUTED HYDROXYAPATITE ; TIO2 NANOTUBES ; IN-VIVO ; CATHODIC ARC ; DIFFERENTIATION ; ADHESION ; SURFACES ; PROLIFERATION ; GROWTH |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000373712800037 |
内容类型 | 期刊论文 |
源URL | [http://ir.sic.ac.cn/handle/331005/23037] |
专题 | 上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文 |
作者单位 | 1.Soochow Univ, Dept Orthopaed, Affiliated Hosp 1, Inst Orthopaed, 188 Shizi St, Suzhou 215006, Peoples R China 2.Jiangnan Univ, Affiliated Hosp, Dept Orthoped, 200 Huihe Rd, Wuxi 214062, Peoples R China 3.Chinese Acad Sci, State Key Lab High Performance Ceram & Superfine, 1295 Dingxi Rd, Shanghai 200050, Peoples R China |
推荐引用方式 GB/T 7714 | Zhao, Xijiang,Wang, Tao,Qian, Shi,et al. Silicon-Doped Titanium Dioxide Nanotubes Promoted Bone Formation on Titanium Implants[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2016,17(3). |
APA | Zhao, Xijiang,Wang, Tao,Qian, Shi,Liu, Xuanyong,Sun, Junying,&Li, Bin.(2016).Silicon-Doped Titanium Dioxide Nanotubes Promoted Bone Formation on Titanium Implants.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,17(3). |
MLA | Zhao, Xijiang,et al."Silicon-Doped Titanium Dioxide Nanotubes Promoted Bone Formation on Titanium Implants".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 17.3(2016). |
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