Continuous Cavitation Designed for Enhancing Radiofrequency Ablation via a Special Radiofrequency Solidoid Vaporization Process

CORC > 上海硅酸盐研究所 > 中国科学院上海硅酸盐研究所 > 高性能陶瓷和超微结构国家重点实验室 > 期刊论文

	Continuous Cavitation Designed for Enhancing Radiofrequency Ablation via a Special Radiofrequency Solidoid Vaporization Process
	Zhang, Kun 1,3; Li, Pei 1; Chen, Hangrong 2; Bo, Xiaowan 1; Li, Xiaolong 1; Xu, Huixiong 1,3
刊名	ACS NANO
	2016-02-01
卷号	10 期号:2 页码:2549-2558
关键词	continuous cavitation radiofrequency ablation triphase transformation radiofrequency solidoid vaporization poly lactide-glycolide acid (PLGA) nanocapsules
英文摘要	Lowering power output and radiation time during radio frequency (RF) ablation is still a challenge. Although it is documented that metal-based magnetothermal conversion and microbubbles-based inertial cavitation have been tried to overcome above issues, disputed toxicity and poor magnetothermal conversion efficiency for metal-based nanoparticles and violent but transient cavitation for microbubbles are inappropriate for enhancing RF ablation. In this report, a strategy, i.e., continuous cavitation, has been proposed, and solid menthol-encapsulated poly lactide-glycolide acid (PLGA) nanocapsules have been constructed, as a proof of concept, to validate the role of such a continuous cavitation principle in continuously enhancing RF ablation. The synthesized PLGA-based nanocapsules can respond to RF to generate menthol bubbles via distinctive radiofrequency solidoid vaporization. (RSV) process, meanwhile significantly enhance ultrasound imaging for HeLa solid tumor, and further facilitate RF ablation via the continuous cavitation, as systematically demonstrated both in vitro and in vivo. Importantly, this RSV strategy can overcome drawbacks and limitations of acoustic droplet vaporization (ADV) and optical droplet vaporization (ODV), and will probably find broad applications in further cancer theranostics.
WOS标题词	Science & Technology ; Physical Sciences ; Technology
类目[WOS]	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]	Chemistry ; Science & Technology - Other Topics ; Materials Science
关键词[WOS]	INTENSITY FOCUSED ULTRASOUND ; DRUG-DELIVERY ; GOLD NANOPARTICLES ; CONTRAST AGENT ; TUMOR-THERAPY ; CHEMOTHERAPY ; RADIATION ; LIVER ; SIZE
收录类别	SCI
语种	英语
WOS记录号	WOS:000370987400097
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/23131]
专题	上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文
作者单位	1.Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Med Ultrasound, 301 Yan Chang Zhong Rd, Shanghai 200072, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram and Superfin, 1295 Ding Xi Rd, Shanghai 200050, Peoples R China 3.Tongji Univ, Sch Med, Ultrasound Res & Educ Inst, 301 Yan Chang Zhong Rd, Shanghai 200072, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Kun,Li, Pei,Chen, Hangrong,et al. Continuous Cavitation Designed for Enhancing Radiofrequency Ablation via a Special Radiofrequency Solidoid Vaporization Process[J]. ACS NANO,2016,10(2):2549-2558.
APA	Zhang, Kun,Li, Pei,Chen, Hangrong,Bo, Xiaowan,Li, Xiaolong,&Xu, Huixiong.(2016).Continuous Cavitation Designed for Enhancing Radiofrequency Ablation via a Special Radiofrequency Solidoid Vaporization Process.ACS NANO,10(2),2549-2558.
MLA	Zhang, Kun,et al."Continuous Cavitation Designed for Enhancing Radiofrequency Ablation via a Special Radiofrequency Solidoid Vaporization Process".ACS NANO 10.2(2016):2549-2558.