RACK1 is required for adipogenesis

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	RACK1 is required for adipogenesis
	Kong, Qinghua 1; Gao, Lan 1,2; Niu, Yanfen 1,3; Gongpan, Pianchou 1,2; Xu, Yuhui 1,2; Li, Yan1,4 ; Xiong, Wenyong1,4
刊名	AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
	2016-11-01
卷号	311 期号:5 页码:C831-C836
关键词	RACK1 3T3-L1 adipogenesis Wnt PI3K-Akt-mTOR-S6K
英文摘要	Adipose tissue plays a critical role in metabolic diseases and the maintenance of energy homeostasis. RACK1 has been identified as an adaptor protein involved in multiple intracellular signal transduction pathways and diseases. However, whether it regulates adipogenesis remains unknown. Here, we reported that RACK1 is expressed in 3T3-L1 cells and murine white adipose tissue and that RACK1 knockdown by shRNA profoundly suppressed adipogenesis by reducing the expression of PPAR-gamma and C/EBP-beta. Depletion of RACK1 increased beta-catenin protein levels and activated Wnt signaling. Furthermore, RACK1 knockdown also suppressed the PI3K-Akt-mTOR-S6K signaling pathway by reducing the PI3K p85 alpha, pAkt T473, and S6K p70. Taken together, these results demonstrate that RACK1 is a novel factor required for adipocyte differentiation by emerging Wnt/beta-catenin signaling and PI3K-Akt-mTOR-S6K signaling pathway(s).
类目[WOS]	Cell Biology ; Physiology
研究领域[WOS]	Cell Biology ; Physiology
关键词[WOS]	RECEPTOR-INTERACTING PROTEIN ; GROWTH-FACTOR-I ; ADIPOCYTE FORMATION ; SCAFFOLD PROTEIN ; KINASE-C ; WNT ; DIFFERENTIATION ; IDENTIFICATION ; MECHANISMS ; GAMMA
收录类别	SCI
语种	英语
WOS记录号	WOS:000390107000013
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/33789]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China 3.Kunming Med Univ, Biomed Engn Res Ctr, Kunming, Peoples R China 4.Yunnan Key Lab Nat Med Chem, Kunming, Peoples R China
推荐引用方式 GB/T 7714	Kong, Qinghua,Gao, Lan,Niu, Yanfen,et al. RACK1 is required for adipogenesis[J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY,2016,311(5):C831-C836.
APA	Kong, Qinghua.,Gao, Lan.,Niu, Yanfen.,Gongpan, Pianchou.,Xu, Yuhui.,...&Xiong, Wenyong.(2016).RACK1 is required for adipogenesis.AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY,311(5),C831-C836.
MLA	Kong, Qinghua,et al."RACK1 is required for adipogenesis".AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 311.5(2016):C831-C836.