Compounds from Polyphaga plancyi and their inhibitory activities against JAK3 and DDR1 kinases

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Compounds from Polyphaga plancyi and their inhibitory activities against JAK3 and DDR1 kinases
	Zhu, Hong-Jie 1,2; Yan, Yong-Ming 2; Tu, Zheng-Chao 3; Luo, Jin-Feng 3; Liang, Rui 3; Yang, Tong-Hua 4; Cheng, Yong-Xian 2; Wang, Shu-Mei 1
刊名	FITOTERAPIA
	2016-10-01
卷号	114 页码:163-167
关键词	Polyphaga plancyi Bolivar Insect Computational methods JAK3 DDR1
英文摘要	Plancyamides A (1) and B (3), plancypyrazine A (2), and plancyols A (4) and B (5), five new compounds (1-5), and three known ones (6-8), were isolated from the whole bodies of Polyphaga plancyi Bolivar. Their structures were elucidated by a combination of spectroscopic analyses including 1D and 2D NMR, and HRESIMS. Among them, compound 3 is racemic, chiral HPLC separation afforded its respective enantiomers. The absolute configuration of 1 was assigned by computational methods. Biological evaluation of all the compounds with exception of 7 and 8 discloses that compounds 2 and 4 could inhibit JAK3 kinase with IC50 values of 12.6 and 5.0 mu M, respectively. In addition, compound 4 exhibit inhibitory activity towards DDR1 kinase with IC50 value of 4.87 mu M. (C) 2016 Elsevier B.V. All rights reserved.
类目[WOS]	Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	INSECT ASPONGOPUS-CHINENSIS ; POLYRHACHIS-DIVES ; DERIVATIVES ; COX-1
收录类别	SCI
语种	英语
WOS记录号	WOS:000386643600023
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/33654]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Guangdong Pharmaceut Univ, Guangzhou 510006, Guangdong, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 3.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China 4.First Peoples Hosp Yunnan Prov, Dept Hematol, Kunming 650032, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Hong-Jie,Yan, Yong-Ming,Tu, Zheng-Chao,et al. Compounds from Polyphaga plancyi and their inhibitory activities against JAK3 and DDR1 kinases[J]. FITOTERAPIA,2016,114:163-167.
APA	Zhu, Hong-Jie.,Yan, Yong-Ming.,Tu, Zheng-Chao.,Luo, Jin-Feng.,Liang, Rui.,...&Wang, Shu-Mei.(2016).Compounds from Polyphaga plancyi and their inhibitory activities against JAK3 and DDR1 kinases.FITOTERAPIA,114,163-167.
MLA	Zhu, Hong-Jie,et al."Compounds from Polyphaga plancyi and their inhibitory activities against JAK3 and DDR1 kinases".FITOTERAPIA 114(2016):163-167.