Brain Formaldehyde is Related to Water Intake Behavior

CORC > 心理研究所 > 中国科学院心理研究所 > 中国科学院心理健康重点实验室

	Brain Formaldehyde is Related to Water Intake Behavior
	Li, Ting 1,6; Su, Tao 1; He, Yingge 1; Lu, Jihui 5; Mo, Weichuan 1; Wei, Yan 1,3; He, Rongqiao 1,2,4
刊名	Aging and Disease
	2016-10-01
卷号	7 期号:5 页码:561-584
关键词	formaldehyde water intake semicarbazide-sensitive amine oxidase arginine vasopressin behavior
ISSN号	2152-5250
英文摘要	A promising strategy for the prevention of Alzheimer's disease (AD) is the identification of agerelated changes that place the brain at risk for the disease. Additionally, AD is associated with chronic dehydration, and one of the significant changes that are known to result in metabolic dysfunction is an increase in the endogenous formaldehyde (FA) level. Here, we demonstrate that the levels of uric formaldehyde in AD patients were markedly increased compared with normal controls. The brain formaldehyde levels of wild-type C57 BL/6 mice increased with age, and these increases were followed by decreases in their drinking frequency and water intake. The serum arginine vasopressin (AVP) concentrations were also maintained at a high level in the 10-month-old mice. An intravenous injection of AVP into the tail induced decreases in the drinking frequency and water intake in the mice, and these decreases were associated with increases in brain formaldehyde levels. An ELISA assay revealed that the AVP injection increased both the protein level and the enzymatic activity of semicarbazide-sensitive amine oxidase (SSAO), which is an enzyme that produces formaldehyde. In contrast, the intraperitoneal injection of formaldehyde increased the serum AVP level by increasing the angiotensin II (ANG II) level, and this change was associated with a marked decrease in water intake behavior. These data suggest that the interaction between formaldehyde and AVP affects the water intake behaviors of mice. Furthermore, the highest concentration of formaldehyde in vivo was observed in the morning. Regular water intake is conducive to eliminating endogenous formaldehyde from the human body, particularly when water is consumed in the morning. Establishing good water intake habits not only effectively eliminates excess formaldehyde and other metabolic products but is also expected to yield valuable approaches to reducing the risk of AD prior to the onset of the disease.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Geriatrics & Gerontology
研究领域[WOS]	Geriatrics & Gerontology
关键词[WOS]	STRESS-INDUCED APOPTOSIS ; AMINE OXIDASE ACTIVITY ; ALZHEIMERS-DISEASE ; TAU HYPERPHOSPHORYLATION ; NEUROBLASTOMA-CELLS ; COLLECTING DUCT ; MEMORY DECLINE ; ANXIETY-LIKE ; CROSS-TALK ; IN-VITRO
收录类别	SCI
语种	英语
WOS记录号	WOS:000392702800003
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/21190]
专题	心理研究所_中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Capital Med Univ, Beijing Inst Brain Disorders, Alzheimers Dis Ctr, Beijing 100069, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 4.Southwest Med Univ, Luzhou 646000, Sichuan, Peoples R China 5.Beijing Geriatr Hosp, Beijing 100095, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Li, Ting,Su, Tao,He, Yingge,et al. Brain Formaldehyde is Related to Water Intake Behavior[J]. Aging and Disease,2016,7(5):561-584.
APA	Li, Ting.,Su, Tao.,He, Yingge.,Lu, Jihui.,Mo, Weichuan.,...&He, Rongqiao.(2016).Brain Formaldehyde is Related to Water Intake Behavior.Aging and Disease,7(5),561-584.
MLA	Li, Ting,et al."Brain Formaldehyde is Related to Water Intake Behavior".Aging and Disease 7.5(2016):561-584.