Oligoethylenimine-Grafted Chitosan as Enhanced T-1 Contrast Agent for In Vivo Targeted Tumor MRI

CORC > 苏州纳米技术与纳米仿生研究所 > 中国科学院苏州纳米技术与纳米仿生研究所 > 纳米生物医学与安全研究部 > 裴仁军团队

	Oligoethylenimine-Grafted Chitosan as Enhanced T-1 Contrast Agent for In Vivo Targeted Tumor MRI
	Tong, XY; Liu, M(刘敏); Zhang, KC(张坤驰); Cao, Y(曹翼); Dong, JJ(董京金); Jiang, B(姜斌); Lu, B; Zheng, H; Zhang, HL(张海禄); Pei, RJ(裴仁军)
刊名	JOURNAL OF MAGNETIC RESONANCE IMAGING
	2016
卷号	44 期号:1
通讯作者	Pei, RJ(裴仁军)
英文摘要	Purpose: To synthesize and characterize an effective macromolecular magnetic resonance imaging (MRI) contrast agent based on oligoethylenimine-grafted chitosan with targeting capability. Materials and Methods: In this study we synthesized and characterized oligoethylenimine-grafted chitosan copolymers, followed by conjugating with Gd-DTPA and folic acid. The toxicity was evaluated by WST assay, and in vitro MRI studies were performed in comparison with Gd-DTPA. Finally, the contrast enhancement of the new macromolecular MRI contrast agent was then evaluated in the mice bearing KB xenografts. Results: Compared to Gd-DTPA (4.3 mM(-1) s(-1)), this macromolecular contrast agent (mCA) exhibited much higher T-1 relaxivity (14.4 mM(-1) s(-1)), up to 3.3 times higher. Meanwhile, the WST assay illustrated that the viability of KB cells remained at 90% even when the Gd concentration was 1 mM. During the in vivo study, the image contrast produced by FA-mCA was higher than one produced by mCA, up to 2.5 times higher. Conclusion: Our results showed this macromolecular contrast agent has potential for developing sensitive and biocompatible MRI probe with targeting capability.
关键词[WOS]	MAGNETIC-RESONANCE ; CANCER-DIAGNOSIS ; DRUG-DELIVERY ; GADOLINIUM ; NANOPARTICLES ; ACID ; NANOPROBE ; OXIDE
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000380067800003
内容类型	期刊论文
源URL	[http://ir.sinano.ac.cn/handle/332007/4695]
专题	苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_裴仁军团队
推荐引用方式 GB/T 7714	Tong, XY,Liu, M,Zhang, KC,et al. Oligoethylenimine-Grafted Chitosan as Enhanced T-1 Contrast Agent for In Vivo Targeted Tumor MRI[J]. JOURNAL OF MAGNETIC RESONANCE IMAGING,2016,44(1).
APA	Tong, XY.,Liu, M.,Zhang, KC.,Cao, Y.,Dong, JJ.,...&Pei, RJ.(2016).Oligoethylenimine-Grafted Chitosan as Enhanced T-1 Contrast Agent for In Vivo Targeted Tumor MRI.JOURNAL OF MAGNETIC RESONANCE IMAGING,44(1).
MLA	Tong, XY,et al."Oligoethylenimine-Grafted Chitosan as Enhanced T-1 Contrast Agent for In Vivo Targeted Tumor MRI".JOURNAL OF MAGNETIC RESONANCE IMAGING 44.1(2016).