Tissue Characterization with Quantitative High-Resolution Magic Angle Spinning Chemical Exchange Saturation Transfer Z-Spectroscopy

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	Tissue Characterization with Quantitative High-Resolution Magic Angle Spinning Chemical Exchange Saturation Transfer Z-Spectroscopy
	Zhou, Iris Yuwen 1,2; Fuss, Taylor L.1,2,3,4; Igarashi, Takahiro 1,2,5; Jiang, Weiping 1,2,6; Zhou, Xin 6; Cheng, Leo L.1,2,3,4; Sun, Phillip Zhe 1,2
刊名	ANALYTICAL CHEMISTRY
	2016-11-01
卷号	88 期号:21 页码:10379-10383
英文摘要	Chemical exchange saturation transfer (CEST) provides sensitive magnetic resonance (MR) contrast for probing dilute compounds via exchangeable protons, serving as an emerging molecular imaging methodology. CEST Z-spectrum is often acquired by sweeping radiofrequency saturation around bulk water resonance, offset by offset, to detect CEST effects at characteristic chemical shift offsets, which requires prolonged acquisition time. Herein, combining high-resolution magic angle spinning (HRMAS) with concurrent application of gradient and rf saturation to achieve fast Z-spectral acquisition, we demonstrated the feasibility of fast quantitative HRMAS CEST Z-spectroscopy. The concept was validated with phantoms, which showed excellent agreement with results obtained from conventional HRMAS MR spectroscopy (MRS). We further utilized the HRMAS Z-spectroscopy for fast ex vivo quantification of ischemic injury with rodent brain tissues after ischemic stroke. This method allows rapid and quantitative CEST characterization of biological tissues and shows potential for a host of biomedical applications.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Analytical
研究领域[WOS]	Chemistry
关键词[WOS]	NUCLEAR OVERHAUSER ENHANCEMENT ; ENCODED CEST SPECTROSCOPY ; AMIDE PROTON-TRANSFER ; MRI CONTRAST AGENTS ; MAGNETIZATION-TRANSFER ; IN-VIVO ; NMR-SPECTROSCOPY ; H-1-NMR SPECTROSCOPY ; SINGLE-SCAN ; HUMAN BRAIN
收录类别	SCI
语种	英语
WOS记录号	WOS:000386991200009
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/9982]
专题	武汉物理与数学研究所_磁共振应用研究部
作者单位	1.Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA 2.Harvard Med Sch, Charlestown, MA 02129 USA 3.Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA 4.Harvard Med Sch, Boston, MA 02114 USA 5.Nihon Univ, Sch Med, Dept Neurol Surg, Div Neurosurg, Tokyo 1738610, Japan 6.Chinese Acad Sci, Wuhan Inst Phys & Math, Natl Ctr Magnet Resonance Wuhan, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Iris Yuwen,Fuss, Taylor L.,Igarashi, Takahiro,et al. Tissue Characterization with Quantitative High-Resolution Magic Angle Spinning Chemical Exchange Saturation Transfer Z-Spectroscopy[J]. ANALYTICAL CHEMISTRY,2016,88(21):10379-10383.
APA	Zhou, Iris Yuwen.,Fuss, Taylor L..,Igarashi, Takahiro.,Jiang, Weiping.,Zhou, Xin.,...&Sun, Phillip Zhe.(2016).Tissue Characterization with Quantitative High-Resolution Magic Angle Spinning Chemical Exchange Saturation Transfer Z-Spectroscopy.ANALYTICAL CHEMISTRY,88(21),10379-10383.
MLA	Zhou, Iris Yuwen,et al."Tissue Characterization with Quantitative High-Resolution Magic Angle Spinning Chemical Exchange Saturation Transfer Z-Spectroscopy".ANALYTICAL CHEMISTRY 88.21(2016):10379-10383.