Control of the interparticle spacing in superparamagnetic iron oxide nanoparticle clusters by surface ligand engineering

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 磁共振应用研究部

	Control of the interparticle spacing in superparamagnetic iron oxide nanoparticle clusters by surface ligand engineering
	Wang, Dan 1; Lin, Bingbing 1; Shen, Taipeng 1; Wu, Jun 1; Hao, Fuhua 2; Xia, Chunchao 3; Gong, Qiyong 3; Tang, Huiru 2; Song, Bin 3; Ai, Hua 1,3
刊名	CHINESE PHYSICS B
	2016-07-01
卷号	25 期号:7
关键词	nanoparticle clusters interparticle spacing ligand exchange magnetization
英文摘要	Polymer-mediated self-assembly of superparamagnetic iron oxide (SPIO) nanoparticles allows modulation of the structure of SPIO nanocrystal cluster and their magnetic properties. In this study, dopamine-functionalized polyesters (DA-polyester) were used to directly control the magnetic nanoparticle spacing and its effect on magnetic resonance relaxation properties of these clusters was investigated. Monodisperse SPIO nanocrystals with different surface coating materials (poly(epsilon-caprolactone), poly(lactic acid)) of different molecular weights containing dopamine (DA) structure (DA-PCL2k, DA-PCL1k, DA-PLA1k)) were prepared via ligand exchange reaction, and these nanocrystals were encapsulated inside amphiphilic polymer micelles to modulate the SPIO nanocrystal interparticle spacing. Small-angle x-ray scattering (SAXS) was applied to quantify the interparticle spacing of SPIO clusters. The results demonstrated that the tailored magnetic nanoparticle clusters featured controllable interparticle spacing providing directly by the different surface coating of SPIO nanocrystals. Systematic modulation of SPIO nanocrystal interparticle spacing can regulate the saturation magnetization (M-s) and T-2 relaxation of the aggregation, and lead to increased magnetic resonance (MR) relaxation properties with decreased interparticle spacing.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Physics, Multidisciplinary
研究领域[WOS]	Physics
关键词[WOS]	T-2 RELAXATION ; MRI ; AGENTS ; RELAXIVITY ; PROBES ; OPTIMIZATION ; DESIGN ; CANCER
收录类别	SCI
语种	英语
WOS记录号	WOS:000384225800063
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/9941]
专题	武汉物理与数学研究所_磁共振应用研究部
作者单位	1.Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 3.Sichuan Univ, West China Hosp, Dept Radiol, Chengdu 610041, Peoples R China
推荐引用方式 GB/T 7714	Wang, Dan,Lin, Bingbing,Shen, Taipeng,et al. Control of the interparticle spacing in superparamagnetic iron oxide nanoparticle clusters by surface ligand engineering[J]. CHINESE PHYSICS B,2016,25(7).
APA	Wang, Dan.,Lin, Bingbing.,Shen, Taipeng.,Wu, Jun.,Hao, Fuhua.,...&Ai, Hua.(2016).Control of the interparticle spacing in superparamagnetic iron oxide nanoparticle clusters by surface ligand engineering.CHINESE PHYSICS B,25(7).
MLA	Wang, Dan,et al."Control of the interparticle spacing in superparamagnetic iron oxide nanoparticle clusters by surface ligand engineering".CHINESE PHYSICS B 25.7(2016).